Laboratory of Biophysics and Bioinformatics


Laboratory of Biophysics and Bioinformatics
Neuroscience Institute
Lithuanian University of Health Sciences
Eiveniu st. 4
Kaunas LT-50161

Phone:  +370 37 302966


Head of the laboratory:

Prof. Algimantas Kriščiukaitis, PhD,


Asta Kybartaitė-Žilienė, PhD,

Aušra Saudargienė, PhD,

Paulius Čižas, PhD,

Robertas Petrolis, PhD,


Laboratory short history

Laboratory of Biophysics and Bioinformatics was founded in 1990. Its origins go back to 1972, when in the Laboratory of Electrical Stimulation and Defibrillation of the Heart, the research group on electrophysiological was created. In 1982 on the base of cardiac electrophysiology research group the Laboratory of Cardiorythmology and Electrical Stimulation was founded. In 1990 the latter part of the laboratory staff has established Laboratory of Biophysics of Excitable Systems (recent – Laboratory for Biophysics and Bioinformatics).

Objectives of laboratory were: investigations of myocardial passive and active properties under normal conditions and under ischemia, investigation of intercellular communication mechanisms on the single channel level and mathematical modelling of intercellular communication; and evaluation of functional properties of viable tissues and systems: biophysical modelling based multivariate analysis of multimodal biomedical data.


Research topic

Title: Evaluation of functional properties of viable tissues and systems: biophysical modelling based multivariate analysis of multimodal biomedical data

Recent advances in electronics and information technologies opens new possibilities of multimodal registration of acoustical, and electrical signals and optical images in extraordinary variety of spectral bands comprehensively reflecting valuable diagnostical information in multimodal way about wide range of objects, starting from isolated cells, through tissues, organs till systems of whole organism. Effective usage of such possibilities using advanced imaging and mathematical information processing methods opens the way for breakthrough in most actual areas of healthcare. Effective diagnostics, prevention and control of age related degenerative processes in human body could be achieved using biophysical models based imaging and quantitative evaluation methods.

Researchers of Laboratory for Biophysics and Bioinformatics, having sufficient experience and basic technological resources are planning to elaborate biophysical models based biomedical signal and image analysis methods able to detect pathological changes in living tissues and systems, evaluate interrelations of several concurrent processes causing pathogenesis of the diseases. It is planned to create: a specialized methodology for elaboration of tissue structure/pattern evaluation methods; methodology for usage of multivariate analysis for multimodal signals and images; strategies for elaboration of biophysical models based multimodal signal and image analysis for functional properties of organs and systems in human body.

The work will be performed in collaboration with Laboratories of Ophthalmology and Biochemistry, Department of Neurology, and Institute for Digestive Research.


Main projects

2019-2020 – a Partnering Project "Multiscale Hippocampal Models for Neuronal Plasticity: Integration to the Brain Simulation Platform - HippoPlasticity" to the Human Brain Project (HBM) Flagship, head dr. A.Saudargienė

2019 – a project "Scientific visit at the Center for Memory and Brain, Boston University, US", funded through the Research Council of Lithuania, head dr. A.Saudargienė

2018-2022 – EU funded COST Action project CA17121 COMULIS "Correlated Multimodal Imaging In Life Sciences", prof. A.Kriščiukaitis

2018-2022 – collaboration (prof. A.Kriščiukaitis) in the ESF funded project No 01.2.2-LMT-K-718-01-0030 „Personalized wearable technologies for evaluating life-threatening health conditions in chronic kidney disease patients”, head prof. V.Marozas (KTU)

2018-2019 – a project "Mobile internet application for mindfulness based cognitive behavioural therapy", funded by the Research Council of Lithuania, head dr. A.Saudargienė

2018 – bdhk_logo_pdf_istais-page-001.jpg (1754x650)the Baltic-German University Liaison Office project "Synaptic and dendritic dysfunction in Alzheimer‘s disease: computational and experimental neuroscience perspectives to understand the dynamics of neurodegenerative processes", funded by the German Academic Exchange Service (DAAD) with funds from the Foreign Office of the Federal Republic Germany. The aim of the project is to investigate complex interactions of hippocampal CA1 pyramidal neuron deficient cholinergic neuromodulation, synaptic dysfunction and dendritic atrophy due to beta-amyloid peptides accumulation in Alzheimer’s disease applying computational modelling approach. Project leader dr. A.Saudargienė.

2016-2018 – contribute (dr. A.Saudargienė) in the EC programme Horizon 2020 funded project ID 650003 “EU FET Flagship Human Brain Project”

2015-2018 – collaboration (prof. A.Kriščiukaitis) in the project No MIP-15045 “The Impact of focused trasthoracic echocardiography in urgent abdominal surgery for septic patients”, funded by the Research Council of Lithuania, head prof. A.Macas

2013-2015 – collaboration in post doc (dr. Asta Kybartaitė-Žilienė) project BioMONDA "Multimodal data analysis of optic nerve and it's environment based on biophysical models", funded by Research Council of Lithuania, head prof. A.Kriščiukaitis

2013-2015 – collaboration (prof. A.Kriščiukaitis) in the ESF funded project No VP1-3.1-ŠMM-10-V-02-004 “Smart wearable monitoring system for human healthcare”, head prof. A.Lukoševičius (KTU)

2010-2011 – collaboration in the project No MIP-68/2010 „Multivariate analysis based non invasive evaluation of central haemodynamics and prognosis of patient status”, funded by the Research Council of Lithuania, head prof. A.Kriščiukaitis


International collaboration

Université de Rennes 1, France; Pontifícia Universidade Católica do Rio Grande do Sul / Microgravity Centre, Porto Alegre, Brazil; Albert Einstein College, NY, USA; State University of New York, USA; University of Michigan, USA; Free University of Berlin, Germany.


pdf-logo.jpg (90x68, 68x68) 2018 - 2011 main publications


Updated on 9 September 2019