Use this url to cite publication: https://hdl.handle.net/20.500.12512/97508
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The Effect of intravenous paracetamol in combination with nsaids for postoperative pain in children / Goda Miseviciute, Danguolė Česlava Rugytė
Type of publication
Recenzuojamos išplėstinės tezės / Peer-reviewed extended theses (T1d)
Title
The Effect of intravenous paracetamol in combination with nsaids for postoperative pain in children / Goda Miseviciute, Danguolė Česlava Rugytė
Publisher (trusted)
Lithuanian University of Health Sciences |
Date Issued
Date Issued |
---|
2018-05-16 |
Extent
p. 26-28.
Is part of
IHS Conference abstract book / Lithuanian University of Health Sciences. Student Scientific Society ; [Edited by Elvinas Monstavičius, Cover by Kamilė Krauledaitė]. Kaunas : Lithuanian University of Health Sciences, 2018.
Version
Originalus / Original
Field of Science
Abstract
INTRODUCTION Non-steroidal antiinflammatory drugs (NSAIDs) and paracetamol are common agents used for postoperative pain management in paediatric patients worldwide. Various systematic reviews and scientific works prove that NSAIDs decrease not only the requirement of opioids, but also the incidence of their side effects. However, therapeutic superiority of the combination of paracetamol and NSAIDs compared to NSAIDs alone in paediatric patients remains controversial.AIM The purpose of this study is to define if additional intravenous paracetamol may improve analgesia and outcomes in paediatric surgical patients treated with intravenous ketoprofen postoperatively. METHODSA perspective double-blind placebo-controlled random sampling research was conducted. All parents of the children, selected for the study gave their consent. All patients received standard balanced anaesthesia and ketoprofen 4.5 mg/kg/24h postoperatively. Regional blockade has not been applied to any patient. All patients were randomized into two groups. The patients of intervention group in addition to ketoprofen also received intravenous paracetamol 60 mg/kg/24h, while placebo group received 0,9% sodium chloride. Rescue analgesia for postoperative pain varied depending on the severity of surgery: tramadol i/v was used for minor/intermediate operations, and i/v morphine-PCA was administered following major surgery. We measured postoperative pain scores at predefined regular time intervals for 24 hours following surgery by 10 point color analogue scale or FLACC scale. We also evaluated 24 hours opioid requirement in morphine equivalents. We assessed the time until the first spontaneous urination and the first oral intake following surgery. Parent‘s and the child’s satisfaction with general well-being on the first day after surgery as well as side effects, such as nausea and/or vomiting, were also compared among intervention and placebo groups. Statistical analysis was made [...].
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990000958470107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Bibliographic Details
3