Use this url to cite publication: https://hdl.handle.net/20.500.12512/96947
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Does SIRT1 gene polymorphisms play a role in pituitary adenoma recurrence? / G. Morkunaite, A. Vilkeviciute, B. Glebauskiene, L. Kriauciuniene, R. Liutkeviciene
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Author(s)
Title
Does SIRT1 gene polymorphisms play a role in pituitary adenoma recurrence? / G. Morkunaite, A. Vilkeviciute, B. Glebauskiene, L. Kriauciuniene, R. Liutkeviciene
Publisher (trusted)
Vita est Scientia |
Date Issued
Date Issued |
---|
2018-01-03 |
Extent
p. 48-49, no. 38.
Is part of
Vita Scientia : International conference „Vita Scientia“ : conference book : 3rd January, 2018, Vilnius / Vilnius University. Vilnius : Vita est Scientia, 2018, 2018.
Version
Originalus / Original
Series/Report no.
Poster session.
Description
The abstract texts have not been edited.
Bibliogr.: p. 49
Field of Science
Abstract
Pituitary adenomas (PAs) present a lot of clinical signs that include symptoms of excessive hormone secretion by the tumor or hormone deficits by the normal pituitary gland. All changes related to grow the tumor mass and compress of surrounding structures: the optic chiasm, cranial nerves [1]. The present study was performed to determine the association between sirtuin 1 (SIRT1) gene single nucleotide polymorphism and PA development and recurrence. Materials and methods: The study included 70 patients with PA. The reference group involved 162 healthy subjects. The genotyping of SIRT1 rs3740051 was performed using real-time polymerase chain reaction method. Results: Statistical analysis did not reveal significant differences in genotype (AA, AG, GG) distribution between the PA and control groups: 77.1%, 20.0%, 2.9% vs. 86.4%, 12.4%, 1.2%, respectively, p=0.202. SIRT1 rs3740051 polymorphism analysis in subgroups of PA by recurrence revealed differences in the genotype distribution between patients with recurrent PA and controls: G/G genotype was more frequent in patients with recurrent PA compared to healthy controls (12.5% vs. 1.2%, p=0.015). Binomial logistic regression analysis of the patients with recurrent PA and the control group revealed significant variables in the co-dominant (OR=11.667; 95% CI: 1.507-90.328; p=0.019) and recessive (OR=11.429; 95% CI: 1.494-87.425; p=0.019). Analysis of genotype distribution between patients with non-recurrent PA and control group did not exhibit any significant differences (p=0.158). Conclusion: The SIRT1 rs3740051 polymorphism associated with recurrent PA development.
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
2538-791X
Other Identifier(s)
(LSMU ALMA)990000947030107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Bibliographic Details
1