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Influence of atmospheric pressure on the occurrence of ST-elevation myocardial infarction in patients with matrix metalloproteinase-3 polymorphism / Aistė Varoniukaitė, Dovydas Verikas, Vaiva Lesauskaitė, Jonė Venclovienė
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Title
Influence of atmospheric pressure on the occurrence of ST-elevation myocardial infarction in patients with matrix metalloproteinase-3 polymorphism / Aistė Varoniukaitė, Dovydas Verikas, Vaiva Lesauskaitė, Jonė Venclovienė
Date Issued
Date Issued |
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2017-06-01 |
Extent
p. 66-66, no abstr. 53.
Is part of
Medicina : : Abstracts from 26th Nordic-Baltic Congress of Cardiology in Vilnius, Lithuania, June 1-3, 2017. , 2017, vol. 53, suppl. 1.
Version
Originalus / Original
Field of Science
Abstract
Introduction: Studies demonstrated correlation between atmospheric pressure (AP) and occurrence of ST-elevation myocardial infarction (STEMI) [1,2]. The pathophysiology of MI involves matrix metalloproteinases (MMPs) [3], which promote destabilization and rupture of atheromatous plaque [4]. Meanwhile, genetic variation of MMPs expression influences the occurrence of MI [5]. A meta-analysis of MMP-3 5A/6A polymorphism showed that the risk of MI significantly differed between the carriers of the 5A allele and the carriers of the 6A6A genotype [3]. The underlying cause-effect relationship of subjects with different MMP-3 polymorphism and role of AP on the incidence of STEMI remains unclear. Aim. To evaluate the association of MMP-3 5A/6A polymorphism with the occurrence of STEMI according to the changes of AP. Methods: The retrospective study enrolled 336 patients diagnosed with acute STEMI in 2007-2010. Data on MMP-3 (-1171) 5A/6A genotypes distribution was provided by Laboratory of Molecular Cardiology, Institute of Cardiology. The study analyzed the MMP-3 (-1171) 5A/6A genotype distribution and allele frequency according to the AP, set to 2 days before hospitalization due to STEMI, quartiles. Day mean values of AP were determined in the Karmėlava airport meteorological station. Statistical analysis was performed using SPSS 22. Statistical significance was based on an alpha level of 0.05 (p < 0.05). Results: Of 336 examined patients 83 (24.7%) were female, 253 (75.3%) were male. 218 (64.9%) patients were >65 years old. The distribution of 5A5A, 5A6A, 6A6A, genotype in STEMI patients, was 28.0%, 52.4%, 19.6%, respectively. The frequency of alleles in AP quartiles: I quartile - 47.40% 5A and 52.60% 6A, II - 52.38% 5A and 47.62% 6A, III - 55.98% 5A and 44.02% 6A, IV - 61.18% 5A and 38.82% 6A. The frequency of STEMI patients with 5A5A genotype was significantly increasing in AP quartiles. It was 18.8%, 28.6%, 29.3%, 36.5% in I, II, III, IV quartiles, [...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
1648-9233
Other Identifier(s)
(LSMU ALMA)990000935270107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Bibliographic Details
5