Use this url to cite publication: https://hdl.handle.net/20.500.12512/94410
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Influence of left ventricular diastolic dysfunction to the development of pulmonary hypertension in patients with severe aortic stenosis / Birute Gumauskiene, Ausra Krivickiene, Egle Drebickaite, Egle Ereminiene, Jolanta Justina Vaskelyte
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Author(s)
Kardiologijos klinikos gydytojai rezidentai (K110903) | |||
Title
Influence of left ventricular diastolic dysfunction to the development of pulmonary hypertension in patients with severe aortic stenosis / Birute Gumauskiene, Ausra Krivickiene, Egle Drebickaite, Egle Ereminiene, Jolanta Justina Vaskelyte
Publisher (trusted)
Riga Stradiņš University |
Date Issued
Date Issued |
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2016-04-23 |
Extent
p. 9-10.
Is part of
1st Baltic pulmonary hypertension conference : abstracts : April 23, 2016, Riga, Latvia / Riga Stradiņš University. Riga : Riga Stradiņš University, 2016.
Version
Originalus / Original
Field of Science
Abstract
Introduction The development of pulmonary hypertension (PH) in patients with severe aortic stenosis (AS) is associated with clinical deterioration and poor outcomes. Therefore, defining the causes of PH and the clinical markers associated with PH carries significant implications for patient management. Increased LV filling pressure is one of the factors influencing development of PH. The contribution of LV diastolic dysfunction (LVDD) as a determinant of PH in patients with severe AS is not well defined as a tool in clinical practice. Aim To evaluate the impact of Doppler-echocardiographic parameters of LVDD (increased LV filling pressure) as determinants of PH in patients with severe AS. Materials and methods We evaluated 52 patients, who underwent isolated aortic valve replacement, because of severe aortic stenosis (aortic valve area < 1 cm2). Patients with documented coronary heart disease, chronic obstructive pulmonary disease, atrial fibrillation and mitral regurgitation were excluded. Pulmonary systolic pressure (PSP), left atrial (LA) volume and parameters of LV diastolic function (peak early (E) and late (A) diastolic velocities of mitral inflow, E/A ratio, transmitral flow velocity (E)/mitral annular diastolic velocity (E’) ratio) were evaluated on preoperative echocardiographic protocol. Pulmonary hypertension was defined as an estimated PSP > 35 mm Hg. Statistical analysis was performed using SPSS version 21.0. Results We enrolled 52 patients, the mean age was 68,7 ± 7,42 years. There were 25 men (48,1 %) and 27 women (51,9 %). Among these patients, 35 (67,3%) had PH (mean systolic PAP was 43,17 ± 9,35 mmHg) and 17 (32,7%)- hadn’t PH (mean systolic PAP was 31,29 ± 3,18 mmHg). Frequent of comorbidities (arterial hypertension, diabetes) were equal in both groups. Patients with PH had statistically significant worse LV diastolic function parameters, compared with group without PH (E/E’ ratio- 14,95 ± 7,15 vs. 10,89 ± 3,09 (p=0,04); average
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990000895910107106
Coverage Spatial
Latvija / Latvia (LV)
Language
Anglų / English (en)
Affiliation(s)