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Catalase activity in mice brain: the effects of selenium and aliuminium ions / I. Sadauskienė, K. Liekytė, I. Stanevičienė, A. Liekis, L. Ivanov
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Author(s)
Title
Catalase activity in mice brain: the effects of selenium and aliuminium ions / I. Sadauskienė, K. Liekytė, I. Stanevičienė, A. Liekis, L. Ivanov
Publisher (trusted)
Lithuanian Neuroscience Association |
Date Issued
Date Issued |
---|
2014-12-05 |
Extent
p. 36, no. P24.
Is part of
6th Conference of Lithuanian Neuroscience Association : Program and abstracts : 5 December, 2014, Vilnius / Lithuanian Neuroscience Association ; Organizing committee: Osvaldas Rukšėnas, Aidas Alaburda, Rima Naginienė, Inga Griškova-Bulanova, Vilma Kisnierienė, Ramunė Grikšienė. Vilnius : Lithuanian Neuroscience Association, 2014.
Version
Originalus / Original
Series/Report no.
Posters.
Field of Science
Abstract
Neurodegenerative diseases are chronic diseases, which damage the front basal cluster and cortex of brain, produce a significant brain cholinergic dysfunction and manifest themselves as memory, language and behavioral abnormalities. To reduce the risks of these diseases and to treat them successfully it is important to determine the mechanisms of their development. It is believed that those diseases are associated with oxidative damage of brain cells. Very often the cause of oxidative stress is the effect of heavy metals on the functioning of body cells. Metal ions not only cause oxidative stress, but also affect functions of cell enzymes and other important compounds directly. Antioxidant system in the human body protects cells/tissues against damages induced by reactive oxygen species. Catalase is a common enzyme, which catalyzes decomposition of hydrogen peroxide to water and oxygen. It is a very important enzyme in protecting the cell from oxidative damage caused by reactive oxygen species. The aim of this work was to evaluate the effects of selenium and aluminum ions on the catalase activity in brain cells of laboratory mice. Catalase activity was determined in mice brain after a single and 14 days injection of Al3+ , SeO3 2- and (Al3++SeO3 2-) saline solution in the abdominal cavity. The results showed that 24 h after i.p. injection of Al3+ (0.5 LD50), SeO32- (0.025 LD50) or their mix the catalase activity was the same in control and experimental groups. As 0.5 LD50 Al3+ dose for 14 days is lethal, we used these Al3+ doses: 0.1 LD50, 0.15 LD50 and 0.25 LD50. We found that Al3+ caused a statistically significant increase of brain catalase activity, as compared to the control group of mice. Meanwhile, the SeO3 2- and (Al3++SeO3 2-) saline solution injection for 14 days, as well as after 24 h exposure, did not affect brain catalase activity.
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990000856050107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Affiliation(s)