Use this url to cite publication: https://hdl.handle.net/20.500.12512/91068
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Variability of S100 protein in melanoma patients' tissue and serum / Regīna Kleina, Simona Doniņa, Jana Janovska, Ivanda Franckeviča, Anita Dabužinskiene, Inta Nuķe, Lada Korpeikina, Andris Šmits, Ludmila Eņģele
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Author(s)
Kleina, Regīna | Department of Pathology, Rīga Stradiņš University, Rīga, Latvia |
Doniņa, Simona | Department of Pathology, Rīga Stradiņš University, Rīga, Latvia |
Janovska, Jana | Department of Pathology, Rīga Stradiņš University, Rīga, Latvia |
Franckeviča, Ivanda | Department of Pathology, Rīga Stradiņš University, Rīga, Latvia |
Nuķe, Inta | Rīga Eastern Clinical University Hospital, Rīga, Latvia |
Korpeikina, Lada | Rīga Eastern Clinical University Hospital, Rīga, Latvia |
Šmits, Andris | Rīga Eastern Clinical University Hospital, Rīga, Latvia |
Eņģele, Ludmila | Rīga Eastern Clinical University Hospital, Rīga, Latvia |
Title
Variability of S100 protein in melanoma patients' tissue and serum / Regīna Kleina, Simona Doniņa, Jana Janovska, Ivanda Franckeviča, Anita Dabužinskiene, Inta Nuķe, Lada Korpeikina, Andris Šmits, Ludmila Eņģele
Publisher (trusted)
Rīga Stradiņš University |
Date Issued
Date Issued |
---|
2013-11-07 |
Extent
p. 88.
Is part of
Baltic Morphology VII Scientific Conference Morphological Sciences in the Experimental and Clinical Medicine : November 7-9, 2013, Rīga, Latvia : abstract book / Rīga Stradiņš University (RSU). [Institute of Anatomy and Anthropology] ; Committee: Māra Pilmane [et al.]. Rīga : Rīga Stradiņš University, 2013. ISBN 978-9984-793-36-8.
Version
Originalus / Original
Series/Report no.
Veterinary medicine and pathology.
Veterinary medicine and pathology.
Field of Science
Keywords
Abstract
Introduction. S100 is of low molecular weight Ca⁺⁺ binding protein of melanocytes, glial cell, neurons, fibroblasts, cardiac myocytes, epithelium, etc. S100 has been implicated in protein phosphorylation, cell proliferation, neoplastic transformation and differentiation. The information about the role of S100 in tissues is contradictory: from its induction of melanoma (M) progression, it promotes growth and survival of cardiac myocytes up to indication of brain injury. In serum protein S100 is evaluated in screening for M metastasis, recurrence and prognosis. The aim was to evaluate a n umber of S100 marked cells in primary and secondary melanoma and compare it with protein S100 level in serum. Methods. S100 in serum was measured by full automated system using electroche-moluminometric immunoassay. IHC was realised by EnVision kit with S100 antibody in patients with primary and secondary M. S100 marked cells were assessed by calculating the mean cell number counted in three different fields (x400). A number of S100+ cells was graded: I degree: 70-100%, II degree: 30-70% and III degree: 1-30%. The level of S100 in serum of M patients was divided into 2 groups: normal concentration (till 105 pg/ml) and elevated. [...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
978-9984-793-36-8
Other Identifier(s)
(LSMU ALMA)990000828830107106
Coverage Spatial
Latvija / Latvia (LV)
Language
Anglų / English (en)