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Enterovirus infections and type 1 diabetes-international comparison / H.R. Viskari, L. Salur, R. Uibo, D. Marciulionyte, R. Hermann, G. Soltesz, J. Ludvigsson, M. Fuechtenbusch, A. Ziegler, A. Kondrashova, A. Romanov, A. Karvonen, A. Reunanen, J. Ilonen, M. Knip, H. Hyƶty
Type of publication
TezÄs kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Author(s)
Viskari, Hanna | Dep. of Virology, Universities of Tampere, Turku, Finland |
Salur, Liina | Department of Immunology, University of Tartu, Estonia |
Uibo, Raivo | Department of Immunology, University of Tartu, Estonia |
Hermann, Robert | Department of Pediatrics, University of PĆ©cs, PĆ©cs, Hungary |
SoltƩsz, Gyula | Department of Pediatrics, University of PƩcs, PƩcs, Hungary |
Ludvigsson, Johnny | Linkƶping University, Linkƶping, Sweden |
FĆ¼chtenbusch, Martin | |
Ziegler, Anette-Gabriele | Technische UniversitƤt MĆ¼nchen (TUM), Leiterin des Instituts fĆ¼r Diabetes-Forschung an der Klinik und Poliklinik fĆ¼r Kinder- und Jugendmedizin, Germany |
Kondrashova, Anita | Department of Pediatrics, University of Petrozavodsk, Petrozavodsk, Russia |
Romanov, Anatolij | Department of Pediatrics, University of Petrozavodsk, Petrozavodsk, Russia |
Karvonen, Aino | |
Reunanen, Antti | Department of Health and Functional Capacity National Public Health Institute, Helsinki, Finland |
Ilonen, Jorma | |
Knip, Mikael | |
Hyƶty, Heikki |
Title
Enterovirus infections and type 1 diabetes-international comparison / H.R. Viskari, L. Salur, R. Uibo, D. Marciulionyte, R. Hermann, G. Soltesz, J. Ludvigsson, M. Fuechtenbusch, A. Ziegler, A. Kondrashova, A. Romanov, A. Karvonen, A. Reunanen, J. Ilonen, M. Knip, H. Hyƶty
Date Issued
Date Issued |
---|
2001-09-09 |
Extent
p. A 103, no. 393.
Is part of
37th annual meeting of the European Association for the Study of Diabetes (EASD) : abstract volume : Glasgow, Scotland, September 9-13, 2001 / European Association for the Study of Diabetes. Glasgow : EASD, 2001.
Version
Originalus / Original
Series/Report no.
PS 10. Autoimmunity II.
Field of Science
Abstract
Background and Aims: Enterovirus infections have associated with increased risk for Type 1 diabetes in retrospective case-control studies as well as in prospective studies. To study further this association we analysed if the frequency of enterovirus infections correlates with the incidence of Type 1 diabetes when compared between countries with either high or low incidence of diabetes. Materials and Methods: Frequency of enterovirus infections in different populations was studied by analysing enterovirus antibodies in 10-14-year old children in Finland, Sweden, Russia, Estonia, Lithuania, Hungary and Germany. Serum samples (N=120,114,114,106,103,91,104 respectively) were analysed for IgG class antibodies against purified coxsackievirus B4, poliovirus Type 1 and synthetic enterovirus peptide using EIA. The frequency and levels of these antibodies reflect past exposure to enteroviruses and the frequency of enterovirus infection in a given population. Results: The levels of enterovirus antibodies varied a lot between different countries. Median levels (EIU) of peptide antibodies were 42 (Estonia), 19 (Finland), 42 (Germany), 14 (Hungary), 31 (Lithuania), 30 (Sweden), 16 (Russia). The incidence of type 1 diabetes (/100 000) is 10, 37, 11, 6, 6, 25, 7 respectively. Poliovirus antibodies, which arise from polio vaccinations, varied also considerably from the median of 18 EIU in Finland to 42 EIU in Germany. Conclusions: The levels of enterovirus antibodies varied considerably between different countries suggesting variation in the transmission of enterovirus infections. The populations with high incidence of Type 1 diabetes (like Finland) did not have exceptionally high levels of enterovirus antibodies suggesting that high incidence of type 1 diabetes is not necessarily associated with a high frequency of enterovirus infections in the population. The differences in poliovirus antibody levels may refle
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990000523990107106
Coverage Spatial
JungtinÄ KaralystÄ / United Kingdom of Great Britain and Northern Ireland (GB)
Language
Anglų / English (en)