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Role of variants at SIRT1 gene in pituitary adenoma / G. Morkunaite, A. Vilkeviciute, B. Glebauskiene, L. Kriauciuniene, R. Liutkeviciene
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Author(s)
Title
Role of variants at SIRT1 gene in pituitary adenoma / G. Morkunaite, A. Vilkeviciute, B. Glebauskiene, L. Kriauciuniene, R. Liutkeviciene
Publisher (trusted)
Elsevier |
Date Issued
Date Issued |
---|
2017-12-01 |
Extent
p. 121-121, no. P 30.
Is part of
Medicina : 9th International conference of Lithuanian Neuroscience Association „Neurodiversity: from theory to clinics“ : 1 December 2017 : abstracts / Editor in Chief Edgaras Stankevičius. Wrocław : Elsevier, 2017, vol. 53, suppl. 2.
Version
Originalus / Original
Series/Report no.
Poster presentation.
Description
eISSN 1648-9144.
Field of Science
Keywords
Abstract
Background and Aim: Pituitary adenomas (PAs) accounts for approximately 10% off primary brain tumors. It is usually located in the front two-thirds of the pituitary gland and may extend into surrounding structures resulting a lot of complications: headache, visual impairment and behavioral changes (American brain tumor association, 2017). The present study aimed to determine the association between two sirtuin 1 (SIRT1) gene polymorphisms (rs4746720 and rs3740051) and PA development and investigate how they associated with gender. Materials and Methods: The study included 70 patients with a diagnosis of PA. The reference group involved 120 healthy subjects. The genotyping of SIRT1 rs3740051 and rs4746720 were performed using the real-time polymerase chain reaction method. The potential associations with single nucleotide polymorphisms (rs3740051, rs4746720) were evaluated for all patients. Results: Genotyping results revealed that rs4746720 AA variant was observed with a frequency of 100 % in all study groups. Statistical analysis of SIRT1 rs3740051 did not reveal significant differences in genotype (AA, AG, GG) distribution between PA and control groups: 78.6%, 18.6%, 2.8% vs. 85.0%, 14.2%, 0.8%, respectively (p=0.301). Analysis of genotype distribution between females and males did not exhibit any significant differences either: genotype (AA, AG, GG) distribution in PA and control females (79.0%, 18.4%, 2.6% vs. 87.5%, 10.9%, 1.6%, respectively, p=0.517) and in PA and control males (75.0%, 21.9%, 3.1% vs. 82.1%, 17.9%, 0%, respectively, p=0.359). Conclusions: The SIRT1 rs3740051 and rs4746720 polymorphisms were not associated with PA development.
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
1648-9233
Other Identifier(s)
(LSMU ALMA)990000945220107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)