Use this url to cite publication: https://hdl.handle.net/20.500.12512/18440
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Inter- and intra-observer reproducibility of cardiac magnetic resonance feature tracking and sample size calculation in small animals / Tomas Lapinskas, Seyedeh Mahsa Zamani, Sarah Jeuthe, Daniel R. Messroghli, Rolf Gebker, Heike Meyborg, Ulrich Kintscher, Remigijus Zaliunas, Burkert Pieske, Philipp Stawowy, Sebastian Kelle
Type of publication
Tezės Web of Science duomenų bazėje / Theses in Web of Science database (T1a1)
Author(s)
Zamani, Seyedeh Mahsa | German Heart Institute Berlin, Germany |
Jeuthe, Sarah | Charité-Universitätsmedizin Berlin, Germany |
Messroghli, Daniel R. | Charité Universitätsmedizin and Deutsches Herzzentrum Berlin, Germany |
Gebker, Rolf | German Heart Institute Berlin, Germany |
Meyborg, Heike | German Heart Institute Berlin, Germany |
Kintscher, Ulrich | Charité-Universitätsmedizin Berlin, Germany |
Pieske, Burkert | German Heart Institute Berlin, Germany |
Stawowy, Philipp | German Heart Institute Berlin, Germany |
Kelle, Sebastian | German Heart Institute Berlin, Germany |
Title
Inter- and intra-observer reproducibility of cardiac magnetic resonance feature tracking and sample size calculation in small animals / Tomas Lapinskas, Seyedeh Mahsa Zamani, Sarah Jeuthe, Daniel R. Messroghli, Rolf Gebker, Heike Meyborg, Ulrich Kintscher, Remigijus Zaliunas, Burkert Pieske, Philipp Stawowy, Sebastian Kelle
Publisher (trusted)
Is Referenced by
Date Issued
Date Issued |
---|
2017-02-02 |
Extent
p. 416-416, no. P200 : pav.
Is part of
Journal of Cardiovascular Magnetic Resonance. Abstract Supplement: Proceedings from the 20th Annual SCMR Scientific sessions of the Society for Cardiovascular Magnetic Resonance (SCMR 2017) : 2-4 February, 2017, Washington, D.C., United States / Society for Cardiovascular Magnetic Resonance. London : BioMed Central, 2017, vol. 19, suppl., February 1.
Version
Originalus / Original
Field of Science
Abstract
Background: Cardiovascular magnetic resonance feature tracking (CMR-FT) is a novel tissue tracking technique developed for noninvasive assessment of myocardial function. This study aimed to assess the inter- and intra-observer reproducibility of CMR-FT in a small animal (mouse) model and define sample size calculation for future trials. Methods: Six C57BL/6J mice were selected and underwent CMR with a 3 Tesla small animal MRI scanner (MRS 3017, MR Solutions, Guildford, UK). Myocardial deformation was analyzed using dedicated software (TomTec Imaging Systems, 2D CPA, MR, Cardiac Performance Analysis, Unterschleissheim, Germany) by two observers. Left ventricular (LV) longitudinal strain (EllLAX) was calculated from two long-axis cine images, and circumferential and radial strain (EccSAX, ErrSAX) were derived from one mid-ventricular short-axis cine image. To assess intra-observer agreement, all data analysis was repeated 4 weeks after the initial assessment. The sample size required to detect a relative change in strain was calculated. Results: Myocardial deformation parameters were successfully derived in all animals. EccSAX and EllLAX demonstrated highest inter-observer reproducibility (ICC 0.79 (0.46-0.91) and 0.73 (0.56-0.83) for EccSAX and EllLAX respectively). In contrast, at the intra-observer level EllLAX was more reproducible than EccSAX (ICC 0.83 (0.73-0.90) and 0.74 (0.49-0.87) for EllLAX and EccSAX respectively). The reproducibility of ErrSAX was weak at both observer levels. Sample size calculation revealed that detection of a relative 10% change in EccSAX in mice would require ten animals (not measures). In contrast, 85 mice are required to detect a 5% relative change in ErrSAX with CMR-FT (power of 90% and α error of 0.05). Conclusions: Cardiac mechanics parameters derived from conventional cine images using CMR-FT technique in small animal models are highly reproducible. The most reproducible m [...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISSN (of the container)
1532-429X
Other Identifier(s)
(LSMU ALMA)990000921600107106
Coverage Spatial
Jungtinės Amerikos Valstijos / United States of America (US)
Language
Anglų / English (en)
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Journal of Cardiovascular Magnetic Resonance | 7.7 | 1.703 | 2.292 | 2017 | Q1 |