Use this url to cite publication: https://hdl.handle.net/20.500.12512/112389
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Antioxidant Defense Capability of Zinc to Mitigate Nickels Neurotoxicity in Mice / Jurgita Sulinskiene, Rasa Bernotiene, Rima Naginiene
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Title
Antioxidant Defense Capability of Zinc to Mitigate Nickels Neurotoxicity in Mice / Jurgita Sulinskiene, Rasa Bernotiene, Rima Naginiene
Publisher (trusted)
Vilnius University Press |
Date Issued
Date Issued |
---|
2021-11-26 |
Extent
p. 53-53.
Is part of
XIII International Conference of the Lithuanian Neuroscience Association „CONSCIOUSNESS“ (LNA conference) : 26 November 2021, Kaunas, Lithuania : Virtual Conference : Abstract book / Vilnius University. Lithuanian University of Health Sciences. Vytautas Magnus University. Vilnius : Vilnius University Press, 2021. ISBN 9786090706794.
Version
Originalus / Original
Description
no. 30
Poster presentations
ISBN 978-609-07-0679-4 (digital PDF)
Field of Science
Abstract
Introduction. The nervous system is one of the major targets of nickel, as this metal crosses the blood-brain barrier and accumulates in the brain. Ni competes with redox active metals, reduces the activities of the enzymes of antioxidant system, thus causing oxidative stress. Although redox inert zinc isn’t an antioxidant in the true sense of the word, its deficiency is associated with increased free radical generation and weakened response to oxidative stress. The scientific data indicates the ability of Zn to reduce lipid peroxidation, enhance capacity of antioxidant system and suggests potential antagonism with Ni. The aim of present study was to evaluate the antioxidant defense capabilities of Zn on Ni induced brain oxidative damage of mice. To assess oxidative status, contents of reduced glutathione (GSH) and metallothionein (MT) were measured. Methods. Mice were randomly assigned into 3 metal exposure groups plus a control group which received i.p. injections of saline. Mice of Ni and Zn exposure groups received an i.p injections (once a day) of corresponding amounts of NiCl2 and ZnSO4. Mice of the Zn+Ni exposure group were i.p. injected with ZnSO4 and after 20 min with NiCl2 solutions in corresponding doses. Results. Our results have showed that single and repeated Ni2+ administration significantly decreased contents of GSH in the brain of mice by 20 % and 30 % respectively. ZnSO4 administration didn’t seem to affect content of GSH at neither period of exposure, however the injection of Zn2+ 20 minutes prior to the NiCl2 administration has returned GSH concentration to the level of control at both periods of exposure (p<0,05). Brain MT concentrations were increased by 30 % after a single exposure to Ni2+ just as after single Zn2++Ni2+ exposure (p<0,05), however MT concentration in the brain of once Zn2+- treated group of mice remained at control level. Repeated NiCl2 administration increased brain [...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
9786090706794
Other Identifier(s)
(LSMU ALMA)990001049660107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)