Use this url to cite publication: https://hdl.handle.net/20.500.12512/112388
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Effect of Selenium Supplementation on Lipid Peroxidation and Selenium Concentrations in Mice Brain and Blood / Ausrine Ruzgaite, Dale Viezeliene, Arunas Liekis, Vaida Simakauskiene, Inga Staneviciene
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Title
Effect of Selenium Supplementation on Lipid Peroxidation and Selenium Concentrations in Mice Brain and Blood / Ausrine Ruzgaite, Dale Viezeliene, Arunas Liekis, Vaida Simakauskiene, Inga Staneviciene
Publisher (trusted)
Vilnius University Press |
Date Issued
Date Issued |
---|
2021-11-26 |
Extent
p. 49-49.
Is part of
XIII International Conference of the Lithuanian Neuroscience Association „CONSCIOUSNESS“ (LNA conference) : 26 November 2021, Kaunas, Lithuania : Virtual Conference : Abstract book / Vilnius University. Lithuanian University of Health Sciences. Vytautas Magnus University. Vilnius : Vilnius University Press, 2021. ISBN 9786090706794.
Version
Originalus / Original
Description
no. 26
Poster presentations
ISBN 978-609-07-0679-4 (digital PDF)
Field of Science
Abstract
Introduction. Selenium (Se) is a trace element with a wide spectrum of biological action. Despite the low concentration in the body, Se performs various unique functions through antioxidant selenoproteins, that contributes to redox signaling, protein folding, neurochemical signaling. Nevertheless, Se is involved into the diverse functions of the brain including coordination, memory and cognition. However, higher Se doses act as prooxidant and disturb cellular redox balance. Thus, significant changes in Se concentration could be related to neuronal dysfunction and neurodegenerative diseases. This study was performed to evaluate the effect of different Se doses on lipid peroxidation in mice brain and blood. Materials and methods. Experiments were performed on BALB/c mice. Animals were divided into three groups: control group, low-dose Se group (0.2 mg of Se/kg bw/day), highdose Se group (0.4 mg of Se/kg bw/day). Control mice were given tap water, whereas Se treated mice received Na2SeO3 in tap water for 8 weeks. Se concentration was determined by inductively coupled plasma mass spectrometry (using NexION 300 D). Lipid peroxidation was estimated by measuring thiobarbituric-acid-reactive substances and expressed as malondialdehyde (MDA), a marker of lipid peroxidation. License of the State Food and Veterinary Service for working with laboratory animals No. G2-80. Results. The exposure to low-dose Se caused a 3.1-fold increase of Se concentration in mice blood in comparison with Se concentration value (271.23 μg/L, p<0.05) of control. Likewise high blood Se concentration (936.17 μg/L, p<0.05) was noted in mice after administration of high-dose Se. Treatment of mice with low- and high-dose Se, increased Se concentration in mice brain by 138 % (0.145 μg/g, p<0.05) and by 152 % (0.154 μg/g, p<0.05) respectively. It was shown that the decrease in MDA concentration by 41 % in mice blood and by 25 % in the brain afte[...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
9786090706794
Other Identifier(s)
(LSMU ALMA)990001049630107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)