Use this url to cite publication: https://hdl.handle.net/20.500.12512/112385
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Arterial Hypertension Influences Heart Innervation in Aged Experimental Animals / Dalia Ranceviene, Kristina Rysevaite-Kyguoliene, Deimante Sabeckiene, Ignas Sabeckis, Neringa Pauziene
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Title
Arterial Hypertension Influences Heart Innervation in Aged Experimental Animals / Dalia Ranceviene, Kristina Rysevaite-Kyguoliene, Deimante Sabeckiene, Ignas Sabeckis, Neringa Pauziene
Publisher (trusted)
Vilnius University Press |
Date Issued
Date Issued |
---|
2021-11-26 |
Extent
p. 48-48.
Is part of
XIII International Conference of the Lithuanian Neuroscience Association „CONSCIOUSNESS“ (LNA conference) : 26 November 2021, Kaunas, Lithuania : Virtual Conference : Abstract book / Vilnius University. Lithuanian University of Health Sciences. Vytautas Magnus University. Vilnius : Vilnius University Press, 2021. ISBN 9786090706794.
Version
Originalus / Original
Description
no. 25
Poster presentations
ISBN 978-609-07-0679-4 (digital PDF)
Field of Science
Abstract
Objective. To detect changes of cardiac nerves in aged experimental animals due to arterial hypertension. Methods. Aged (46-50 weeks) spontaneously hypertensive rats (SHR, n=3, systolic blood pressure >150 mmHg) and Wistar-Kyoto rats (WKY, n=3, systolic BP<150 mmHg) of similar weight (g) 377±4 vs. 330±45 were studied. The 2-dimensional echocardiography was performed to evaluate cardiac anatomy and showed an enlarged left ventricle chamber in the hypertension group. Neural structures were stained immunohistochemically for general neuronal marker PGP 9.5. The diameter of the atrial and ventricular epicardial nerves was measured in wholemount preparations. Also, ventricular myocardial innervation in the right and left ventricles and septum was measured using threshold function in transverse cryosections and expressed in percentages (%). Results were described as mean ± standard error and compared by Student t or Mann-Whitney U test, p-value<0.05. Results. In both groups of rats, epicardial nerves were abundant and showed highly replicable patterns of innervation in the left dorsal region of the atrium. The diameter of SHR and WKY atrial epicardial nerves in this specific region differed significantly (25±0.9 vs. 31±1.8 μm, p=0.001), and it was smaller in the SHR group. Ventricular epicardial nerves access walls of cardiac ventricles throughout the arterial part of the heart hilum at the roots of ascending aorta and pulmonary trunk and on the dorsal side from the heart hilum venous portion in both groups equivalently. The diameter of nerves was greater in the hypertensive group (SHR 33±15 vs. WKY 24±1.5 μm, p<0.001), probably because the left ventricle chamber was enlarged and needed more innervation. The ventricular myocardial nerve fiber meshwork was different in all three segments. The innervation was denser in SHR in the right ventricle (SHR 1.8±0.06% vs. WKY 1.14±0.04%, p<0.000) and septum (SHR 0.4[...].
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
9786090706794
Other Identifier(s)
(LSMU ALMA)990001049620107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Funding(s)
Funding(s) | Project ID |
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Research Council of Lithuania | no. S-MIP-19-23 |