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Arterial hypertension change phenotype of nerve fibers in epicardiac nerves / Dalia Ranceviene, Joana Azukaite, Kristina Rysevaite - Kyguoliene, Neringa Pauziene
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Title
Arterial hypertension change phenotype of nerve fibers in epicardiac nerves / Dalia Ranceviene, Joana Azukaite, Kristina Rysevaite - Kyguoliene, Neringa Pauziene
Publisher (trusted)
Institute for Clinical and Functional Anatomy Medical University |
Date Issued
Date Issued |
---|
2021-09-21 |
Extent
p. 35-35.
Is part of
115th Annual Meeting = 115th Anatomische Gesellschaft Meeting : September 21-23, 2021, Insbruck, Austria. Insbruck : Institute for Clinical and Functional Anatomy Medical University, 2021.
Version
Originalus / Original
Description
no. P30
Neuroanatomy
Field of Science
Abstract
To detect early changes of epicardiac nerves’ due to arterial hypertension. Transverse ventricular cryosections of 7 spontaneously hypertensive rats (SHR), 6 Wistar-Kyoto rats (WKY) were examined in juvenile (<2 months) and adult (>3 months) groups. Neural structures were stained immunohistochemically for protein gene product 9.5 (PGP95 – general neuronal marker) and calcitonin gene-related peptide (CGRP – potent vasodilator). Total epicardiac nerve cross-section area and area stained with both neuromarkers were measured and their ratio expressed as percentage. Results were described as means and compared by Student t-test, p-value<0.05. In juvenile WKY (n=151) vs SHR (n=162) nerves comparative area of PGP9.5 (72.5% vs 73.3%), CGRP (4.7% vs 5.9%) did not differ p>0.050, but CGRP/PGP9.5 ratio (6.7% vs 8.2%) was higher in SHR, p=0.009. In the adult WKY (n=49) vs SHR (n=111), PGP9.5 was lower in SHR by 12.1% (81.6% vs 71.7%), p<0.000, as well as CGRP was lower by 20.62% (5.5% vs 4.4%), p=0.040. CGRP/PGP9.5 ratio did not differ between adult groups (6.8% vs 6.0%), p=0.304. Comparing the SHR according to the age, PGP9.5 distribution remained similar. However, in SHR, comparative area of CGRP and CGRP/PGP9.5 ratio were lower in the adult group by 25.0% and 26.0%, respectively, p=0.001. In contrast, there was a 12.4% increase in PGP9.5 in the WKY adult group, p<0.000, although the CGRP distribution and CGRP/PGP9.5 ratio did not differ, p=0.897. Neural and vasodilator components were more plentiful in juvenile rats however decreased in the adult spontaneously hypertensive rats; in opposite – both components increased in control group with ageing.
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990001046550107106
Coverage Spatial
Austrija / Austria (AT)
Language
Anglų / English (en)