Use this url to cite publication: https://hdl.handle.net/20.500.12512/110990
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Safety of Preprocedural Sedation with Midazolam: a Clinical Practice from a Lithuanian Pediatric Emergency Department / Albors Daemi, Goda-Camille Mickeviciute, Ignas Sutkevicius, Algirdas Dagys, Milda Seskute, Lina Jankauskaite
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Author(s)
Sutkevičius, Ignas | ISM Vadybos ir ekonomikos universitetas, UAB |
Title
Safety of Preprocedural Sedation with Midazolam: a Clinical Practice from a Lithuanian Pediatric Emergency Department / Albors Daemi, Goda-Camille Mickeviciute, Ignas Sutkevicius, Algirdas Dagys, Milda Seskute, Lina Jankauskaite
Publisher (trusted)
European Society for emergency medicine |
Date Issued
Date Issued |
---|
2020-09-19 |
Extent
p. 530-530.
Is part of
European Emergency Medicine Congress – EuSEM 2020 : virtual Congress : 19-22 September : abstract book / European Society for Emergency Medicine. Aartselaar : European Society for emergency medicine, 2020.
Version
Originalus / Original
Description
Field of Science
Abstract
Background: Midazolam is one of the most commonly used sedative agents in procedural sedation. Yet, it is a very widely discussed topic in pediatrics and controversies about its usage persists. This study was conducted to determine the safety and efficacy of midazolam as well as the frequency, occurrence, and severity of adverse drug reactions. Methods: a pilot observational study was conducted in the Hospital of Lithuanian University of Health Sciences pediatric emergency department (PED). We included children presenting to PED who required preprocedural sedation. The primary endpoint was to evaluate the occurrence of midazolam associated side effects. We used descriptive statistical methods. OR and Rr were used for dichotomous variables. CI of 95% was calculated. P-value <0.05 was considered as statistically significant. Results: We included 31 children in this study (mean age – 4.5±3.6 years). Minor side effects were recorded in 21 (67.7%) of the cases. Severe side effects were not recorded. In 25% paradoxical reactions were observed. 85% of all side effects were recorded with the dosage of <0.3mg/kg. Correlation between the occurrence of side effects and type of procedure (laceration repair) was found (RR:2.34, CI-95% 1.3-4.57; p=0.0057). A lower dosage (<0.26mg/kg) was associated with either diminished heart rate, blood pressure, respiratory rate or oxygen saturation. A higher chance for side effects was observed with oral as compared to intranasal application. Conclusions: The Midazolam administration route, as well as the dosage, has to be carefully evaluated beforehand. It is important to follow-up the patient after the procedure, since we detected minor adverse reactions in most patients that could have been undetected otherwise.
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990001037400107106
Coverage Spatial
Belgija / Belgium (BE)
Language
Anglų / English (en)