Use this url to cite publication: https://hdl.handle.net/20.500.12512/109537
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Value of supar biomarker and lung ultrasound for the prediction of early kidney graft function / Andrėjus Bura, Rūta Skaistė Mačionytė, Marius Bardauskas, Rūta Vaičiūnienė, Inga Arūnė Bumblytė
Type of publication
Konferencijų tezės nerecenzuojamame leidinyje / Conference theses in non-peer-reviewed publication (T2)
Title
Value of supar biomarker and lung ultrasound for the prediction of early kidney graft function / Andrėjus Bura, Rūta Skaistė Mačionytė, Marius Bardauskas, Rūta Vaičiūnienė, Inga Arūnė Bumblytė
Date Issued
Date Issued |
---|
2020-12-11 |
Extent
p. 27-27.
Is part of
XV Baltic Nephrology Conference “UpToDate in Nephrology, Dialysis and Kidney Transplantation” : Online Conference abstract book : 11-12 December 2020 . [S.l.] : Lietuvos nefrologijos, dializės ir transplantacijos asociacija (LNDTA), 2020.
Version
Originalus / Original
Description
no. P11
Poster Abstracts
Bibliogr. : 27
Field of Science
Abstract
Background: Certain pre-and post-transplant causes can lead to delayed function of the transplanted kidney. This study aimed to test whether demographic data, body hydration status, level of soluble urokinase-type plasminogen activator receptor (suPAR) biomarker could predict early kidney graft function. Methods: We examined patients, who underwent cadaveric kidney transplantation (Tx) from 2016/11/01 to 2020/10/01 in the Hospital of Lithuanian University of Health Sciences. Demographic data and data on routine laboratory tests were collected. For evaluating body hydration we performed lung sonography (LU) and bioelectrical impedance analysis (BIA) before Tx and 3-5 days after (n=76 (61.3%). We evaluated the level of suPAR biomarker before Tx and 3 days after (n= 17). On follow-up, 2 groups of patients were distinguished: immediately graft function (IGF) and slow graft function (SGF). Results: SGF was observed in 57 (45.9%), of 124 patients. The development of SGF was associated with longer donor cold ischemia (17.6±5.1 hours vs 15.5 ±4.5 hours; p=0.02), hyperhydration measured by LU before Tx (1.2±1.8 B lines vs 0.3±0.8 lines; p=0.01) as compared to the IGF group. BIA measures were not different between groups. The level of suPAR before Tx was not related to early graft function. But 3 days after Tx there was suPAR reduction in the IGF group, but remaining high level in the SGF group (6±2 vs 8.8 ±2.2; p=0.04). No other tested factors were related to SGF. Conclusion: Lung hyperhydration before kidney transplantation and longer cold ischemia time is associated with slow graft function. SuPAR level was higher 3 days after transplantation in the slow graft function group. Bigger sample size is needed for evaluation of suPAR value in kidney transplantation.
Type of document
type::text::conference output::conference proceedings::conference paper
Other Identifier(s)
(LSMU ALMA)990001029000107106
Coverage Spatial
Lietuva / Lithuania (LT)
Language
Anglų / English (en)
Bibliographic Details
5