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Formulation of Liposomes Containing Royal Jelly and Their Quality Assessment / Kristina Perminaite, Anna Maria Fadda, Chiara Sinico, and Kristina Ramanauskiene
Type of publication
Straipsnis Web of Science duomenų bazėje / Article in Web of Science database (S1a)
Author(s)
Fadda, Anna Maria | Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy |
Sinico, Chiara | Department of Life and Environmental Sciences, University of Cagliari, Italy |
Title
Formulation of Liposomes Containing Royal Jelly and Their Quality Assessment / Kristina Perminaite, Anna Maria Fadda, Chiara Sinico, and Kristina Ramanauskiene
Publisher (trusted)
Amer Scientific Publishers |
Is Referenced by
Date Issued
Date Issued |
---|
2021-01-02 |
Extent
p. 2841-2846.
Is part of
Journal of Nanoscience and Nanotechnology. Valencia : Amer Scientific Publishers, 2021, vol. 21, n. 5.
Version
Originalus / Original
Field of Science
Abstract
Royal jelly, a gelatinuous consistency bee product produced and secreted by the hypopharyngeal and mandibular glands of worker honeybees, is beneficial in the treatment of dermatological con- ditions, likely through its content of the fatty acid 10-hydroxy-2-decenoic acid (10-HDA). However, 10-HAD poorly penetrates into skin. Thus, in this work, we produced royal jelly incorporated lipo- somes with the aim of increasing skin penetration of 10-HDA. Lipid nanocarriers were prepared by the thin lipid-film hydration method. Size and polydispersity index of the nanocarrier particles, and their stability over 30 days were measured. The effects of royal jelly and 10-HDA liposomal formulations on the viability of immortalized human keratinocyte cells were tested with the 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The skin penetration of 10-HDA from liposomal formulations and royal jelly solution was studied in vitro with Franz type vertical diffusion cells using porcine skin as limiting membrane. As result, small liposomes were achieved, and the efficacy of the obtained nanoformulations was examined by means of in vitro cell assays with a HaCaT immortalized human keratinocyte cell culture line. Finally, the skin penetration experiments showed that liposomal incorporation greatly increased 10-HDA penetration into skin layers.
Type of document
type::text::journal::journal article
ISSN (of the container)
1533-4880
1533-4899
Other Identifier(s)
(LSMU ALMA)990001015690107106
Coverage Spatial
Jungtinės Amerikos Valstijos / United States of America (US)
Language
Anglų / English (en)
Bibliographic Details
24