Use this url to cite publication: https://hdl.handle.net/20.500.12512/106278
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Faecal microbiota transplantation for an immunosuppressed patient after recurrent clostridium difficile colitis / Liveta Sereikaitė, Monika Jasinskaitė, Simas Stiklioraitis; Scientific research supervisor: Domas Vaitiekus
Type of publication
Tezės kitame recenzuojamame leidinyje / Theses in other peer-reviewed publication (T1e)
Title
Faecal microbiota transplantation for an immunosuppressed patient after recurrent clostridium difficile colitis / Liveta Sereikaitė, Monika Jasinskaitė, Simas Stiklioraitis; Scientific research supervisor: Domas Vaitiekus
Other(s)
Tyrimo grupės vadovas / Research group head |
Publisher (trusted)
Rīga Stradiņš University |
Date Issued
Date Issued |
---|
2020-03-27 |
Extent
p. 286-286.
Is part of
Rīga Stradiņš University International Student Conference “Health Sciences” 70 year anniversary : (Rīga, 27-28 March 2020) : abstract book. Health Sciences / Layout: Ilze Stikāne ; Rīga Stradiņš University (RSU). Rīga : Rīga Stradiņš University, 2020. ISBN 9789934892714.
Version
Originalus / Original
Series/Report no.
Case reports, case report series.
Description
ISBN 978-9934-8927-1-4.
Field of Science
Abstract
Introduction. A case of a patient with transplanted (Tx) kidney with immunosuppression who underwent autologous hematopoietic stem cell transplantation (AutoHSCT) had faecal microbiota transplantation (FMT) after Cl. difficile colitis (CDC). Case description. A 36-year-old man had kidney transplantation in 2007 and was treated with immunosuppressants (sirolimus MMF). In 2010 he was diagnosed with a metastatic mixed germinal tumour and orchofuniculectomy was performed. The patient underwent first-line chemotherapy of carboplatin, etoposide, bleomycin (4 courses). After chemotherapy during lymphadenectomy mature teratoma was found in lymph nodes and Tx kidney partial resection was performed. After treatment patient remained dialysis-free. In 2017 disease progression was diagnosed. First-line chemotherapy was started and AutoHSCT was deemed necessary. Three AutoHSCT were performed, each of Tx kidney complicated by CDC and sepsis. The patient was consulted by nephrologists, immunosuppression of Tx kidney was reduced. FMT was recommended for the treatment of recurrent CDC in immunosuppressed conditions. This requires the introduction of a nasojejunal tube by endoscopy, thus requiring a platelet count > 50 x10*9/l. After both procedures were performed, no complications were observed. After AutoHSCT patient underwent stereotactic radiation therapy to residual masses (Tx kidney). One year after treatment patient is in CR, dialysis-free with minimal immunosuppression (sirolimus only). Conclusions. The patient transplantation process was complicated by CDC. He got antibiotics after all AutoHSCT episodes. FMT was appropriate for more than two CDC episodes treated with antibiotics. This procedure is safe even after AutoHSCT. Summary. CDC is a common, potentially serious complication of the use of antibiotics. The case report shows that FMT can represent both a safe and effective therapy for complicated CDC even in an acutely ill patient who underwent more than two [...]
Type of document
type::text::conference output::conference proceedings::conference paper
ISBN (of the container)
9789934892714
Other Identifier(s)
(LSMU ALMA)990001006120107106
Coverage Spatial
Latvija / Latvia (LV)
Language
Anglų / English (en)