Laboratory of Molecular Neurobiology
Address:Laboratory of Molecular NeurobiologyNeuroscience InstituteLithuanian University of Health SciencesEiveniu st. 4Kaunas LT-50161Lithuania
Phone number: +370 37 302967
Head of the Laboratory:
Andrius Kaselis, PhD, firstname.lastname@example.org
prof. Ilona Sadauskienė, PhD, email@example.com
Aistė Jekabsone, PhD, firstname.lastname@example.org
Rasa Bernotienė, PhD, email@example.com
Arūnas Liekis, PhD, firstname.lastname@example.org
In 1976, a group of scientists in Department of Biological and Bioorganic Chemistry began to study the biochemical peculiarities of energy generation in tissue repair. This group was the core of Pathochemistry Laboratory, founded in 1979. In 1982, the Laboratory was integrated into the structure of the Central Research Laboratory. Extending their scientific research, in 1983 some of the scientists assigned to the independent Laboratory of Physical and Chemical Research, renamed in 1988 into Laboratory of Clinical Chemistry. In 1992, the laboratories merged into the Laboratory of Pathochemistry of Institute for Biomedical Research. In 2011, the Laboratory of Pathochemistry was reorganized into the Laboratory of Molecular Neurobiology of Neuroscience Institute.
Title: The role of the oxidative stress in aging
The aging appears to be one of the main reasons causing many of neurodegenerative diseases.This study is intended to evaluate the changes of the antioxidant defence system activity in the brain and other organs, during aging and to answer the question whether natural antioxidants are good for healthy aging. It is planned to assess the antioxidant defence system activity and lipid peroxidation of the laboratory animals of different ages; to determine the biochemical mechanisms of the impact of prooxidants in animal organs; to assess the effects of natural antioxidants on the cellular antioxidant defence system; and to evaluate the apoptosis in the organs of different ages animals, exposed to either prooxidants and antioxidants.
The results will be important both for researchers, working in the field of gerontology and for pharmaceutical specialists, developing natural medicines and supplements known to have antioxidant properties.
The Laboratory participates in a project of the Advanced Pharmaceutical and Health Technologies Centre of Lithuanian University of Health Sciences. The researchers have access and are actively using open access facilities of the Laboratory for Pharmacological Regulation of Pathological Processes and Research of Drug Metabolism.
2011-2012 – joint LSMU and Institute of Public Health and Environment (Bilthoven, The Netherlands) project “Are supplements good for healthy ageing?”
Institute of Public Health and Environment (Bilthoven, The Netherlands), University of Aarhus (Denmark), University of New York (USA).
|2017 - 2011 main publications (53,66 KB)|
Updated on 6th November 2017