Laboratory of Clinical Research


Laboratory of Clinical Research
Neuroscience Institute
Lithuanian University of Health Sciences
Eiveniu st. 4
Kaunas LT-50009

Phone number:  +370 37 326164


Head of the laboratory:

Ramūnas Jokubka, PhD,


Adomas Bunevičius, PhD,

Aistė Pranckevičienė, PhD,

Alina Vilkė, PhD student,

Andrius Radžiūnas, PhD student,


Short history

Laboratory was established in 2011, and currently involved in research of neurodegenerative diseases.


Research topic

Title: Neuroendocrine and psychological prognostic biomarkers in brain disorders

Brain disorders are often incurable and debilitating diseases associated with progressive disability and poor prognosis. The prognostic value of currently available clinical prognostic models remains sub-optimal and should be improved in order to allow more accurate assessment of disease severity, clinical outcomes and patient-oriented outcomes. Certain psychological (i.e., psychological distress) and neuroendocrine (i.e., thyroid hormones) factors can be important biomarkers of outcomes in brain disorders; however, further studies aiming to elucidate the prognostic value of these prognostic factors are warranted. Patient-oriented outcomes are becoming increasingly used when evaluating treatment efficacy and patient prognosis, especially among patients suffering from incurable and debilitating disorders, such as brain tumours.

The main goal of our Laboratory is to identify novel neuroendocrine and psychological markers associated with disease severity, clinical sequalea and patient-oriented outcomes of patients suffering from brain disorders.

These findings can potentially improve accuracy of currently available prognostic models and open new avenues for developing more effective treatment strategies of brain disorders.


Main projects

2015-2018 – project No MIP‐15482 BRAINflame "Psychological distress, inflammatory factors, brain natriuretic peptide and outcomes of patients with brain tumor", funded by by the Research Council of Lithuania

2012-2016 – EC 7FP project No 318652 OpenScienceLink: Open Semantically-enabled, Social-aware Access to Scientific Data

2013-2015 – contribute in the Global grant project* VP1-3.1-ŠMM-07-K-02-060 „Gene-Environment Interactions Connecting Low Triiodothyronine Syndrome and Outcomes of Cardiovascular Disease (GET-VASC)” (leaded by habil.dr. R.Bunevičius)


International collaboration

Prof. Edward R. Laws, Harvard University, Department of Neurosurgery, Brigham and Women’s Hospital, Boston, Massachusetts, USA

Prof. Giorgio Iervasi, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy

Prof. Susan S. Girdler, Department of Psychiatry, University of North Carolina at Chapel Hill, USA

Prof. Charles B. Nemeroff, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA

Prof. Victor JM Pop and Pof. Johan Denollet, Center of Research on Psychology in Somatic diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, The Netherlands


pdf-logo.jpg (90x68, 68x68)   2011 - 2015 main publications (140KB) 


Updated on 27th May 2016