Laboratories

  • Laboratory of Biophysics and Bioinformatics

    Address:

    Laboratory of Biophysics and Bioinformatics
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania
     

    Phone:  +370 37 302966

     

    Head of the laboratory:

    Prof. Algimantas Kriščiukaitis, PhD, algimantas.krisciukaitis@lsmuni.lt

    Personnel:

    Asta Kybartaitė-Žilienė, PhD, asta.kybartaite@lsmuni.lt

    Aušra Saudargienė, PhD, ausra.saudargiene@lsmuni.lt

    Paulius Čižas, PhD, paulius.cizas@lsmuni.lt

    Robertas Petrolis, PhD, robertas.petrolis@lsmuni.lt

     

    Laboratory short history

    Laboratory of Biophysics and Bioinformatics was founded in 1990. Its origins go back to 1972, when in the Laboratory of Electrical Stimulation and Defibrillation of the Heart, the research group on electrophysiological was created. In 1982 on the base of cardiac electrophysiology research group the Laboratory of Cardiorythmology and Electrical Stimulation was founded. In 1990 the latter part of the laboratory staff has established Laboratory of Biophysics of Excitable Systems (recent – Laboratory for Biophysics and Bioinformatics).

    Objectives of laboratory were: investigations of myocardial passive and active properties under normal conditions and under ischemia, investigation of intercellular communication mechanisms on the single channel level and mathematical modelling of intercellular communication; and evaluation of functional properties of viable tissues and systems: biophysical modelling based multivariate analysis of multimodal biomedical data.

     

    Research topic

    Title: Evaluation of functional properties of viable tissues and systems: biophysical modelling based multivariate analysis of multimodal biomedical data

    Recent advances in electronics and information technologies opens new possibilities of multimodal registration of acoustical, and electrical signals and optical images in extraordinary variety of spectral bands comprehensively reflecting valuable diagnostical information in multimodal way about wide range of objects, starting from isolated cells, through tissues, organs till systems of whole organism. Effective usage of such possibilities using advanced imaging and mathematical information processing methods opens the way for breakthrough in most actual areas of healthcare. Effective diagnostics, prevention and control of age related degenerative processes in human body could be achieved using biophysical models based imaging and quantitative evaluation methods.

    Researchers of Laboratory for Biophysics and Bioinformatics, having sufficient experience and basic technological resources are planning to elaborate biophysical models based biomedical signal and image analysis methods able to detect pathological changes in living tissues and systems, evaluate interrelations of several concurrent processes causing pathogenesis of the diseases. It is planned to create: a specialized methodology for elaboration of tissue structure/pattern evaluation methods; methodology for usage of multivariate analysis for multimodal signals and images; strategies for elaboration of biophysical models based multimodal signal and image analysis for functional properties of organs and systems in human body.

    The work will be performed in collaboration with Laboratories of Ophthalmology and Biochemistry, Department of Neurology, and Institute for Digestive Research.

     

    Main projects

    2018 – bdhk_logo_pdf_istais-page-001.jpg (1754x650)the Baltic-German University Liaison Office project "Synaptic and dendritic dysfunction in Alzheimer‘s disease: computational and experimental neuroscience perspectives to understand the dynamics of neurodegenerative processes", funded by the German Academic Exchange Service (DAAD) with funds from the Foreign Office of the Federal Republic Germany. The aim of the project is to investigate complex interactions of hippocampal CA1 pyramidal neuron deficient cholinergic neuromodulation, synaptic dysfunction and dendritic atrophy due to beta-amyloid peptides accumulation in Alzheimer’s disease applying computational modelling approach. Project leader dr. A.Saudargienė.

    2016-2018 – contribute in the EC programme Horizon 2020 funded project ID 650003 “EU FET Flagship Human Brain Project”, dr. A.Saudargienė

    2013-2015 – collaboration in post doc project BioMONDA "Multimodal data analysis of optic nerve and it's environment based on biophysical models", funded by Research Council of Lithuania, head prof. A.Kriščiukaitis, dr. Asta Kybartaitė-Žilienė

    2010-2011 – collaboration in project „Multivariate analysis based non invasive evaluation of central haemodynamics and prognosis of patient status” No. MIP-68/2010, funded by Research Council of Lithuania, head prof. A.Kriščiukaitis

     

    International collaboration

    Université de Rennes 1, France; Pontifícia Universidade Católica do Rio Grande do Sul / Microgravity Centre, Porto Alegre, Brazil; Albert Einstein College, NY, USA; State University of New York, USA; University of Michigan, USA; Free University of Berlin, Germany.

     

    pdf-logo.jpg (90x68, 68x68) 2017 - 2011 main publications

     


    Updated on 11 September 2018

  • Laboratory of Biochemistry

    Address:
    Laboratory of Biochemistry
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania
     

    Phone:  +370 37 302968

     

    Head of the laboratory:

    prof. Vilmantė Borutaitė, PhD,  vilmante.borutaite@lsmuni.lt

    Personnel:  

    prof. Ramunė Morkūnienė, PhD, ramune.morkuniene@lsmuni.lt

    prof. Sonata Trumbeckaitė, PhD, sonata.trumbeckaite@lsmuni.lt

    prof. Rasa Banienė, PhD, rasa.baniene@lsmuni.lt

    Julius Liobikas, PhD, julius.liobikas@lsmuni.lt

    Daiva Majienė, PhD, daiva.majiene@lsmuni.lt

    Odeta Arandarčikaitė, PhD, odeta.arandarcikaite2@lsmuni.lt

    Kristina Škėmienė, PhD, kristina.skemiene@lsmuni.lt

    Paulius Čižas, PhD, paulius.cizas@lsmuni.lt

    Silvija Jankevičiūtė, PhD, silvija.jankeviciute@lsmuni.lt

    Katryna Pampuščenko, PhD student, katryna.pampuscenko@lsmuni.lt

    Zbigniev Balion, PhD student, zbigniev.balion@lsmuni.lt

    Danielius Umbrasas, PhD student, danielius.umbrasas@lsmuni.lt

     

    Research topic

    Title: The investigation of cell death and protective mechanisms in models of brain ischemia, neurodegenerative and other diseases

    Protein aggregates containing beta amyloid (Aβ) and other multimeric proteins are critical factors in the pathogenesis of neurodegenerative diseases (including Alzheimer's disease) by causing synaptic dysfunction, neuronal death and loss. Molecular mechanism by which protein aggregates cause death of brain cells and activation of neuroimmune processes will be investigated. Alongside, search and investigation of possible pharmacological modulators of the processes involved will be performed.

    The study also will focus on mechanisms of ischemic mitochondrial damage in brain tissue. The possible sites of ischemic damage in mitochondria will be determined and the possible protective pharmacological agents against ischemic mitochondrial injury will be tested. In the frame of the Global Grant project, cultures of human inducible pluripotent stem cells will be introduced as a model to investigate how human cells die and how to protect them from ischemic damage. A wide comparative analysis of effects of ischemia and reperfusion on immature, mature and aging brain cells (neurons, astrocytes and microglia) will be performed to test whether potential inhibitors of mitochondrial permeability transition pore can protect against ischemia-induced cell death or inflammatory responses in the brain and help to restore functional activity of neurons.

    We are going to determine which compounds (synthetic and natural), acting separately or in combination with pharmacological compounds, are able to suppress viability of brain cancer cells, mitosis/interphase cycle, proliferation and migration of cells in the model systems. We are planning to reveal possible molecular mechanisms of action of those compounds in model systems. We expect that obtained data will pave the way for the in vivo studies on mice glioma allograft and human/mice xenograft models, and will allow us to confirm and specify in vitro data.

    The Laboratory has expertise in primary neuronal and transformed cell cultures; cell biology; potentiometric methods using oxygen, nitric oxide and ion-selective electrodes; spectroscopy, fluorescent microscopy, protein chemistry, DIGE, etc.          

     

    Main projects

    2018-2020 – Lithuania–Japan collaboration program project “Investigation of molecular factors of Alzheimer’s disease: link between extracellular tau, beta-amyloid and neuroinflammation”, funded by the Research Council of Lithuania, head prof. R.Morkūnienė, participants prof. V. Borutaitė, K.Pampuščenko

    2017-2021 – Global grant project No LMT-K-712-01-0131 "Dissecting ischemic brain injury: role of mitochondrial permeability transition pore in cells of developing and aging brain", head prof. V.Borutaitė

    2017-2021 – EU funded COST Action project CA16225 “Realising the therapeutic potential of novel cardioprotective therapies” (EU-CARDIOPROTECTION), prof. V.Borutaitė, dr. O.Arandarčikaitė

    2016-2020 - EU funded COST Action project  MITOEAGLE “Mitochondrial mapping: Evolution - Age - Gender - Lifestyle - Environment", prof. V.Borutaitė

    2016 m. – project No. PR16-82 "Imaging of live tissue/models' mimetics", supported by Joint Stock Company Ferentis, dr. A.Jekabsone

    2015-2018 – collaboration in the project No SEN-01/2015 „Optimizing the effectiveness of Hyperthermic chemotherapy by modulation of heat shock proteins, energy resources and adhesion in malignant cells“, prof. S.Trumbeckaitė

    2015-2016 – collaboration in EU Horizon 2020 project No 664339 HEALTH-TECH “Centre of Excellence in Science and Technology for Healthy Ageing", prof. V.Borutaitė

    2015 – project No VP2-1.3-ŪM-02-K-04-016 "Investigation of interaction of cells with customer's prototypic hydrogel samples in vitro", managed by Lithuanian Business Promotion Agency, dr. A.Jekabsone

    2013-2015 – EU funded COST Action project FA 1005 INFOGEST "Improving health properties of food by sharing our knowledge on the digestive process", dr. J.Liobikas, dr. S.Trumbeckaitė

    2012-2015 – contribute in the Global grant project* VP1-3.1-ŠMM-07-K-02-062 "Energetic, genetic and epigenetic mechanisms of resistance to chemotherapy induced apoptosis in pancreatic cancer", dr. S.Trumbeckaitė

    2012-2014 – project LIG-04/2012 MALPAMA "Molecular mechanisms of pathogenesis of Alzheimer’s disease” (n collaboration with Institute of Biochemistry, and Institute of Biotechnology of Vilnius University, Department of Neurology of Lithuanian University of Health Sciences Hospital), funded by Research Council of Lithuania, dr. R.Morkūnienė

    2012-2014 – ESF project VP1-3.1-ŠMM-08-K-01-022 „Implementation of R&D activities of Medicine National Research Programmes in clinical and molecular research of fundamental cardiology, neurosciences, and digestive systems“, dr. G.Svirskis, prof. V.Borutaitė

    2012-2014 – contribute in the project LIG-12002 STELLATA „Investigation of activity and redox status of Pancreatic Stellate Cells", funded by the Research Council of Lithuania, dr. S.Trumbeckaitė

     2011-2015 – Global grant project* VP1-3.1-ŠMM-07-K-01-130 “Mitochondria, nitric oxide and cytochrome c reducing agents in protection against brain and heart ischemia-reperfusion injury”, head prof. V.Borutaitė

    2011-2014 – project SVE-11008 HIBRIDAI „Interspecific hybrids of orchard plant – a novel source of anthocyanins“, funded by the Research Council of Lithuania, head dr. J.Liobikas

    2010-2011 – project MIP-10182 "The evaluation of biological activity and technological functionalization of lectins", dr. J.Liobikas, dr. D.Majienė

    2008-2010 – project AMILOIDE “Detection of pathogenic beta-amyloid oligomers for diagnostics of Alzheimer’s disease”, funded by Lithuania State Science and Studies Foundation, head prof. V.Borutaitė

    2007-2011 – EU funded COST Action project FA0602 MITOFOOD (A research community for nutritional optimization of mitochondrial function for health promotion and disease resistance), Lithuania deputy prof. V.Borutaitė

    2006-2009 – EUREKA project E! 3694 PROPOCREAM „The development of the multifunctional semisolid preparations from natural products“, dr. D.Majienė

    2006-2007 – EC 6FP Marie Skłodowska-Curie project MERG-CT-2006-044907 MITOCHONDRIA & ABETA (Mitochondria and beta-amyloid in brain ischemia/reperfusion), dr. A.Jekabsone

    2004-2006 – EC 6FP Marie Skłodowska-Curie project CT-2004-010313 MITOCHONDRIA (Role of nitric oxide/oxygen competition at mitochondria in neuronal death during ischemia and/or inflammation), dr. A.Jekabsone

     

    The Laboratory participates in a project of the Advanced Pharmaceutical and Health Technologies Centre of Lithuanian University of Health Sciences. The researchers have access and are actively using open access facilities of the Laboratory for Pharmacological Regulation of Pathological Processes and Research of Drug Metabolism.

     

    International collaboration

    Dr. Guy Brown, Department of Biochemistry, University of Cambridge, UK

    Dr. Erich Gnaiger, Department of General, Visceral and Transplant Surgery, Daniel Swarovski Research Laboratory, Innsbruck Medical University, Innsbruck, Austria

     

    Other important information

    In 2012, prof. V.Borutaitė was awarded with Osvalds Šmidebergs Medal of Latvian Society of Pharmacology.

    In 2008, prof. A.Toleikis, prof. V.Borutaite, prof. V.Mildaziene (former member of the laboratory) were awarded with Lithuanian National Price for Science.

    Members of the Laboratory in collaboration organized the 4th MiPsummer School on Mitochondrial Physiology in Druskininkai, Lithuania on June 10-16, 2010.

     

    pdf-logo.jpg (90x68, 68x68)  2017 - 2011 main publications

     


    Updated on 11 September 2018

  • Laboratory of Behavioral Medicine

    Address:

    Laboratory of Behavioral Medicine (Kaunas)
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania
     

    Phone number:  +370 37 326164

     

    Head of the laboratory:

    Adomas Bunevičius, PhD, MD, adomas.bunevicius@lsmuni.lt 

    Personnel:

    Ramūnas Jokubka, PhD, ramunas.jokubka@lsmuni.lt

    Aistė Pranckevičienė, PhD, aiste.pranckeviciene@lsmuni.lt

    Andrius Radžiūnas, PhD, andrius.radziunas@kaunoklinikos.lt

    Miglė Kaminskaitė, PhD student, migle.kaminskaite@lsmuni.lt

    Mindaugas Urbonas, PhD student, mindaugas.urbonas@kaunoklinikos.lt

     

     

    Address:

    Laboratory of Behavioral Medicine (Palanga)
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Vyduno al. 4/ Sliupo st. 7
    Palanga LT-00135
    Lithuania
     

     

    Personnel:

    Narseta Mickuvienė, PhD, narseta.mickuviene@lsmuni.lt

    Prof. Giedrius Varoneckas, Habil. Sc., giedrius.varoneckas@lsmuni.lt

    Julija Brožaitienė, Habil. Sc., julija.brozaitiene@lsmuni.lt

    Vesta Steiblienė, PhD, vesta.steibliene@lsmuni.lt

    Arvydas Martinkėnas, PhD, arvydas.martinkenas@lsmuni.lt

    Aurelija Podlipskytė, PhD, aurelija.podlipskyte@lsmuni.lt

    Violeta Žaliūnaitė, PhD, violeta.zaliunaite@lsmuni.lt

    Vaidutė Gelžinienė, PhD, vaidute.gelziniene@lsmuni.lt

    Julius Neverauskas, PhD, julius.neverauskas@lsmuni.lt

    Laima Sapežinskienė, PhD, laima.sapezinskiene@lsmuni.lt

    Julius Burkauskas, PhD, julius.burkauskas@lsmuni.lt

    Vilija Jakumaitė, PhD, vilija.jakumaite@lsmuni.lt

    Alicja Juškienė, PhD, alicja.juskiene@lsmuni.lt

    Dalia Martinaitienė, PhD, dalia.martinaitiene@lsmuni.lt

    Audrius Alonderis, audrius.alonderis@lsmuni.lt

    Nijolė Kažukauskienė, nijole.kazukauskiene@lsmuni.lt

    Vilma Liaugaudaitė, PhD student, vilma.liaugaudaite@lsmuni.lt

    Saulius Taroza, PhD student, saulius.taroza@lsmuni.lt

    Julija Gečaitė, PhD student, julija.gecaite@lsmuni.lt

    Brigita Vaičiūnienė, brigita.vaiciuniene@lsmuni.lt

    Giedrė Žalytė, giedre.zalyte@fc.lsmuni.lt

    Adelė Grinevičienė, adele.grineviciene@lsmuni.lt

    Audronė Maruškienė, audrone.maruskiene@lsmuni.lt

    Violeta Augustinienė, violeta.augustiniene@lsmuni.lt

    Laima Eidukienė, laima.eidukiene@lsmuni.lt

    Virginija Jasienė, virginija.jasiene@lsmuni.lt

    Jolanta Kvietkauskienė, jolanta.kvietkauskiene@fc.lsmuni.lt

    Elena Bovina, elena.bovina@lsmuni.lt

    Nijolė Raškauskienė, nijole.raskauskiene@lsmuni.lt

    Alė Vonsavičienė, ale.vonsaviciene@lsmuni.lt

    Vilma Zadonskaja, vilma.zadonskaja@lsmuni.lt

    Rytis Sapežinskas, rytis.sapezinskas@lsmuni.lt

     

     

    Short history

    Laboratory was established in 2011, and currently involved in research of neurodegenerative diseases. In 2018, after reorganisation, got the name of Laboratory of Behavioral Medicine.

     

    Research topic

    Title: Neuroendocrine and psychological prognostic biomarkers in brain disorders

    Brain disorders are often incurable and debilitating diseases associated with progressive disability and poor prognosis. The prognostic value of currently available clinical prognostic models remains sub-optimal and should be improved in order to allow more accurate assessment of disease severity, clinical outcomes and patient-oriented outcomes. Certain psychological (i.e., psychological distress) and neuroendocrine (i.e., thyroid hormones) factors can be important biomarkers of outcomes in brain disorders; however, further studies aiming to elucidate the prognostic value of these prognostic factors are warranted. Patient-oriented outcomes are becoming increasingly used when evaluating treatment efficacy and patient prognosis, especially among patients suffering from incurable and debilitating disorders, such as brain tumours.

    The main goal of our Laboratory is to identify novel neuroendocrine and psychological markers associated with disease severity, clinical sequalea and patient-oriented outcomes of patients suffering from brain disorders.

    These findings can potentially improve accuracy of currently available prognostic models and open new avenues for developing more effective treatment strategies of brain disorders.

    Laboratory of Psychosomatic Research

    Laboratory of Clinical Physiology and Rehabilitation

     

    Main projects

    2018 – LSMU-VDU funded project "Genetic predisposition to alcohol addiction and associated personality traits GVPRAVSAB", head dr. R.Jokubka

    2017-2021 – EU funded COST action project CA16207 "Problematic Internet Use", managament committee members dr. A.Bunevičius, dr. J.Burkauskas

    2017-2020 – collaboration in the project No S-MIP-17-257 "Psychosocial suicide risk factors and accessibility of help in the environment of persons’ who committed suicide", funded by the Research Council of Lithuania, V.Liaugaudaitė

    2015-2018 – project No MIP‐15482 BRAINflame "Psychological distress, inflammatory factors, brain natriuretic peptide and outcomes of patients with brain tumor", funded by by the Research Council of Lithuania, head dr. A.Bunevičius

    2012-2016 – EC 7FP project No 318652 OpenScienceLink: Open Semantically-enabled, Social-aware Access to Scientific Data, habil.dr. R.Bunevičius (2012-2014), dr. A.Bunevičius

    2013-2015 – The Global grant project* VP1-3.1-ŠMM-07-K-02-060 „Gene-Environment Interactions Connecting Low Triiodothyronine Syndrome and Outcomes of Cardiovascular Disease (GET-VASC)”, head habil.dr. R.Bunevičius (2012-2014), habil.dr. J.Brožaitienė (2014-2015)

    2012-2014 - project No LIG-03/2012 "Relations among heart diseases, psycho-emotional  and  sleep disturbances; their impact on life quality", funded by the Research Council of Lithuania, head prof. G.Varoneckas

    2011-2013 – project No LIG-03/2011 "Impact of mental disorders and metabolic syndrome on mortality in primary health care patients", funded by the Research Council of Lithuania, head habil.dr. R.Bunevičius

    2011 – project No LIG-04/2011"Factors determining quality of life and outcomes in patients with ischemic heart disease", funded by the Research Council of Lithuania, head dr. N.Mickuvienė

    2010-2013 – EU funded 7FP project  “A challenge on large-scale biomedical sematic indexing and question answering BioASQ”, Lithuania deputy habil.dr. R.Bunevičius

    2010-2013 – EU funded 7FP project No 247945 “Efficient Patient Recruitment for Innovative Clinical Trials of Existing Drugs to other Indications PONTE”, Lithuania deputy habil.dr. R.Bunevičius

     

     

    International collaboration

    Prof. Edward R. Laws, Harvard University, Department of Neurosurgery, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Prof. Giorgio Iervasi, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy

    Prof. Susan S. Girdler, Department of Psychiatry, University of North Carolina at Chapel Hill, USA

    Prof. Charles B. Nemeroff, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA

    Prof. Victor JM Pop and Pof. Johan Denollet, Center of Research on Psychology in Somatic diseases (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, The Netherlands


    Journal "Biological Psychiatry and Psychopharmacology"

     

    pdf-logo.jpg (90x68, 68x68)  2017 - 2011 main publications
    pdf-logo.jpg (90x68, 68x68)  2017 - 2010 main publications of Behavioral Medicine Institute

     


    Updated on 11 September 2018

  • Laboratory of Molecular Neurobiology

    Address:

    Laboratory of Molecular Neurobiology
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania
     

    Phone number:  +370 37 302967

     

    Head of the Laboratory:

    Kęstutis Skauminas, M.D., PhD; kestutis.skauminas@lsmuni.lt

    Personnel:

    prof. Ilona Sadauskienė, PhD, ilona.sadauskiene@lsmuni.lt

    Aistė Jekabsone, PhD, aiste.jekabsone@lsmuni.lt

    Rasa Bernotienė, PhD, rasa.bernotiene@lsmuni.lt

    Arūnas Liekis, PhD, arunas.liekis@lsmuni.lt

     

     

    Laboratory history

    In 1976, a group of scientists in Department of Biological and Bioorganic Chemistry began to study the biochemical peculiarities of energy generation in tissue repair. This group was the core of Pathochemistry Laboratory, founded in 1979. In 1982, the Laboratory was integrated into the structure of the Central Research Laboratory. Extending their scientific research, in 1983 some of the scientists assigned to the independent Laboratory of Physical and Chemical Research, renamed in 1988 into Laboratory of Clinical Chemistry. In 1992, the laboratories merged into the Laboratory of Pathochemistry of Institute for Biomedical Research. In 2011, the Laboratory of Pathochemistry was reorganized into the Laboratory of Molecular Neurobiology of Neuroscience Institute.

     

    Research topic

    Title: The role of the oxidative stress in aging

    The aging appears to be one of the main reasons causing many of neurodegenerative diseases.This study is intended to evaluate the changes of the antioxidant defence system activity in the brain and other organs, during aging and to answer the question whether natural antioxidants are good for healthy aging. It is planned to assess the antioxidant defence system activity and lipid peroxidation of the laboratory animals of different ages; to determine the biochemical mechanisms of the impact of prooxidants in animal organs; to assess the effects of natural antioxidants on the cellular antioxidant defence system; and to evaluate the apoptosis in the organs of different ages animals, exposed to either prooxidants and antioxidants.

    The results will be important both for researchers, working in the field of gerontology and for pharmaceutical specialists, developing natural medicines and supplements known to have antioxidant properties.

     

    Main projects

    2017-2021 – project No 01.2.2-LMT-K-718-01-0036 EXOTARGET „Exosome application for targeted drug delivery“, funded by the Research Council of Lithuania, dr. A.Jekabsone

    2017-2019 – EC programme Horizon 2020 M-Era.Net project No S-M-ERA.NET-17-2 „Engineering and functionalization of delivery system with Pelargonium sidoides biologically active substance on inflamed periodontal surface area“ (PELARGODONT), co-coordinator dr. A.Jekabsone

     

     

    International collaboration

    Institute of Public Health and Environment (Bilthoven, The Netherlands), University of Aarhus (Denmark), University of New York (USA).

     

    pdf-logo.jpg (90x68, 68x68)  2017 - 2011 main publications 

     


    Updated on 11 September 2018

  • Laboratory of Molecular Neurooncology

    Adress:

    Laboratory of Molecular Neurooncology
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania
     
    Phone: +370 37 326769
    Fax: +370 37 795482

     

    Head of Laboratory:

    Kęstutis Skauminas, M.D., PhD

    Phone +370 37 326883

    E-mail kestutis.skauminas@lsmuni.lt

     

    Personnel:

    prof. Vytenis Pranas Deltuva, M.D. PhD, vytenis.deltuva@lsmuni.lt

    Arūnas Kazlauskas, PhD, arunas.kazlauskas@lsmuni.lt

    Daina Skiriutė, PhD, daina.skiriute@lsmuni.lt

    Paulina Vaitkienė, PhD, paulina.vaitkiene@lsmuni.lt

    Giedrius Steponaitis, PhD, giedrius.steponaitis@lsmuni.lt

    Rūta Urbanavičiūtė, PhD student, ruta.urbanaviciute@lsmuni.lt

    Indrė Valiulytė, PhD student, indre.valiulyte@lsmuni.lt

    Rytis Stakaitis, PhD student, rytis.stakaitis@lsmuni.lt

    Jūratė Žeglienė, jurate.zegliene@lsmuni.lt

    Bernadeta Masiulionytė, bernadeta.masiulionyte@lsmuni.lt

     

    Laboratory short history

    The Laboratory of Neurosciences was established on April 28th 1978, as a sub-division of the Oncology Scientific-Research Institute, Ministry of Health Care. The task of Laboratory was to organize additional scientific research to analyze the central regulation of brain and systematic blood circulation. In the structure of Oncology Institute, it was referred to as the Nervous System Surgery Department while Department of Neurosurgery of Kaunas Medicine Institute Clinics was appointed as its clinical basis. In due course, namely in 1982, the Laboratory moved from Oncology Institute to Central Scientific-Research Laboratory of Kaunas Medicine Institute and was renamed into Nervous System Surgery Laboratory. In 2005 the Laboratory was renamed into the Laboratory of Neurosciences and in 2011, after reorganisation, Laboratory got the name of Neurooncology and Genetics, and functions in the structure of Neuroscience Institute of Lithuanian University of Health Sciences. In 2011 Laboratory got the name of Neurooncology and Genetics and in 2018, after reorganisation, got the name of Molecular Neurooncology .

     

    Research topic

    Title: Research on molecular markers and etiopathogenesis of rare CNS diseases for optimisation of diagnosing and treatment

    The main trends of research work are: research of clinical, etiopathogenetic, radiological factors, playing a decisive role in the course of CNS tumours and the accumulation of pathological material for the investigation for new combinations of clinical genetic and epigenetic markers in diagnosis and prognosis, research on diagnostic molecular markers in glioblastoma and pituitary adenoma, optimisation of the surgical diagnosing of cerebral gliomas using innovative optical technologies. 

    The main goal of these studies is to estimate the complex of molecular markers (projects GREAT and GlioPRoSer) and clinical factors valuable for rare CNS diseases diagnosis and prognosis, to identify molecular factors that are responsible for the initiation of cancerogenesis in CNS cells (project "Novel systems of prodrug activation for the cancer gene therapies") and to evaluate the possibilities of combination of intraoperative tissue identification methods by segmentation of intraoperative magnetic resonance, 3D ultrasound and fluorescence images for optimal visualization of brain tumours.

    Objectives: with the use of cell culturing facilities, to develop procedures necessary for isolation, cultivation and identification of glioma tumour stem cells (GTSC) and by using a number of molecular biology techniques such as Western blot analysis, real-time PCR, and protein co-precipitation, to investigate the composition of transcription regulatory complexes of genes that determine invasiveness of GTSCs.                                             Enlarge picture:labofmolecularneurooncology.jpg (250x170, 188x170)

    Research on epigenetic alterations (DNA methylation, chromatine modifications, miRNAs, etc.) of genes associated with oncogenesis, invasion and resistance to therapy of glioblastoma; research on association between gene epigenetic alterations and gene expression (at mRNA and protein level) in glioblastoma tissue; investigation of the influence on certain gene expression and function of epigenetic promoter alterations (DNA methylation, chromatine remodeling), caused by in vitro manipulating cell culture; selection on the relevance of epigenetic alterations and gene expression diagnostically meaningful genes or gene complexes in glioblastoma and pituitary adenoma. Employing three imaging modalities there will be created methodology for coregistration of 3D interlinked information. There will be investigated methods for quantification and segmentation of FS, US and MRI images. Processing of interrelated images is planned to implement in optimised algorithms to support tissue discrimination. 

    The information and experience obtained from this research could be used for developing new diagnostic methods and developing a methodology for the search for new therapeutic agents against rare CNS diseases.

     

    Main projects

    2018 – a project "NRP1 gene expression in different grade gliomas", funded through the Research Council of Lithuania, head I.Valiulytė

    2018 – a project "Long-non coding RNA HOTAIR and CASC2 gene expression in glioblastomas", funded through the Research Council of Lithuania, head dr. D.Skiriutė

    2017-2020 – project No S-MIP-17-108 "The prognostic value of miRNA classifier as a novel tool for prediction of glioma patient outcome and response to therapy", funded by the Research Council of Lithuania, dr. P.Vaitkienė

    2015-2018 – collaboration in the project No SEN-07/2015 „Novel systems of prodrug activation for the cancer gene therapies“, of the National Programme "Healthy Aging" funded by the Research Council of Lithuania, dr. A.Kazlauskas

    2015-2018 – project "New genetic and metabolic biomarkers search in healthy subjects and patients with age-related macular degeneration", funded by the Research Council of Lithuania, head prof. V.P.Deltuva

    2015-2018 – project GlioProSer "Quantitative serum profiles estimation of proteins related to glioma angiogenesis and invasiveness”, funded by the Research Council of Lithuania, head dr. D.Skiriutė

    2014-2016 – contribute in the project MIP-008/2014 "New molecular prognostic markers search in pituitary adenomas and associations with visual functions", funded by the Research Council of Lithuania, dr. R.Liutkevičienė

    2014-2015 – collaboration in the Lithuanian-Ukrainian project "Identification and characterization of novel biomarkers for human glial tumors", head dr. P.Vaitkienė

    2012-2015 – contribute in the Global grant project* VP1-3.1-ŠMM-07-K-02-060 „Gene-Environment Interactions Connecting Low Triiodothyronine Syndrome and Outcomes of Cardiovascular Disease (GET-VASC)”, dr. D.Skiriutė

    2012-2014 – project LIG-12003 "Gene expression and function-based identification of biomarkers for diagnosis of glioma malignancies", funded by the Research Council of Lithuania, head dr. A.Kazlauskas

    2010-2011 – project “Low T3 syndrome impact on the outcomes after the brain tumour surgery”, funded by the Research Council of Lithuania, head dr. V.P.Deltuva

    2010-2011 – project „The investigation for new combinations of clinical and epigenetic markers in diagnosis and prognosis“, funded by the Research Council of Lithuania, head prof. A.Tamašauskas

    2007-2009 – post doc project "Research on molecular markers of recurrence in benign and malignant meningiomas", funded by Lithuania State Science and Studies Foundation, head prof. A.Tamašauskas, dr. D.Skiriutė

    2006-2008 – ESF project ESF/2004/2.5.0-03-385/BPD-210/ES2006-01 "Implementation of advanced studies for medical physics technologies and nanophotonics", dr. K.Skauminas

    2006-2008 – ESF project BPD2004-ERPF-1.5.0-12-05/0035 “Centre for science and studies of medical physics technologies and nanophotonics”, dr. K.Skauminas

    2006 – project “Intraoperative fluorescentic imaging of brain tumour gliomas”, funded by Lithuania State Science and Studies Foundation

     

    pdf-logo.jpg (90x68, 68x68)  2017 - 2011 main publications

     


    Updated on 11 September 2018

  • Laboratory of Neurophysiology

    Address:

    Laboratory of Neurophysiology
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania
     

    Phone number:  +370 37 302958

     

    Head of the laboratory:

    Gytis Svirskis, PhD, gytis.svirskis@lsmuni.lt

    Personnel:

    Gytis Baranauskas, PhD, gytis.baranauskas@lsmuni.lt

    Nataša Svirskienė, PhD, natasa.svirskiene@lsmuni.lt

    Gražina Grebliauskienė, grazina.grebliauskiene@lsmuni.lt

     

    Laboratory short history

    Laboratory of Neurophysiology continues research themes started earlier by three previous neuroscience laboratories. In 1957, Laboratory of EEG in Kaunas Institute of Medicine was created. Later, Laboratory of Neurophysiology and Laboratory of Neurocybernetics were created. Scientific research was carried out in several directions: experimental – investigating the nature of high and low frequency biocurrents in the brain; pharmacological – investigating influence of pharmacological substances on biocurrents; theoretical – investigating biophysical nature of brain potentials and properties of dendrites with nonlinear electrical properties; clinical – investigating EEG, neurological characteristics and activity spreading pathways in epilepsy and other brain injuries. Since then 21 PhD and 5 Habil. Sc. dissertations were prepared and defended in these laboratories.

     

    Research topic

    Title: Investigation of neural network mechanisms and their relationship to behaviour

    Identification of the relation between neuronal activity and behaviour is necessary in order to understand the function and pathology of the nervous system. Since Alzheimer disease disrupts collision detection, the study of neuronal mechanisms of this behaviour could be important in early detection of the disease. We will study neuronal network spontaneous and induced activity in in vitro and in vivo mammalian cortex, colliculus superior and frog tectum by applying visual stimulation, neuronal registration and methods of molecular biology.

    The investigation will aim at elucidation of synaptic and membrane mechanisms of neuronal network spontaneous and evoked activity.

     

    Main projects

    2012-2015 – Global grant project* VP1-3.1-ŠMM-07-K-02-059 „Investigation of sensory information processing and attention mechanisms by employing genetic modification of neuronal act", head dr. T.Tkatch

    2012-2014 – project MIP-045/2012 „Nicotinic modulation of neuronal column activity", funded by the Research Council of Lithuania, head habil.dr. A Kuras

    2012-2014 – ESF project VP1-3.1-ŠMM-08-K-01-022 „Implementation of R&D activities of Medicine National Research Programmes in clinical and molecular research of fundamental cardiology, neurosciences, and digestive systems“, dr. G.Svirskis, prof. V.Borutaitė

    2011-2012 – project MIP-11298 “Interactions between tectal neuronal responses evoked by two visual stimuli”, funded by the Research Council of Lithuania, head dr. G.Svirskis

    2010-2011 – project „Investigation of synaptic co-transmission in frog retinotectal synapses“, funded by the Research Council of Lithuania, head habil.dr. A.Kuras

    2008 – project “Implication of bistability of frog recurrent tectal neurons in the activation of NMDA receptors”, funded by Lithuania State Science and Studies Foundation, head habil.dr. A.Kuras

    2007 – project “Investigation of dendritic currents elicited in frog tectum neurons by individual retinotectal input”, funded by Lithuania State Science and Studies Foundation, head habil.dr. A.Kuras

    2005 – project “Investigation of influence of frog moving-edge detector on tectal neuron network”, funded by Lithuania State Science and Studies Foundation, head habil.dr. A.Kuras

    2004 – project „NMDA receptor activation in frog tectum neurons“, funded by Lithuania State Science and Studies Foundation, head habil.dr. A.Kuras

     

    International collaboration

    Copenhagen University (Denmark), New York University (USA), University of Oslo (Norway).

     

    pdf-logo.jpg (90x68, 68x68)  2017 - 2011 main publications

     


    Updated on 11 September 2018

  • Laboratory of Toxicology

    Address:

    Laboratory of Toxicology
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania
     

    Phone:  +370 37 302948

     

    Head of the laboratory:

    Rima Naginienė, PhD, rima.naginiene@lsmuni.lt

    Personnel:

    Loreta Strumylaitė, PhD, loreta.strumylaite@lsmuni.lt

    Rima Kregždytė, PhD, rima.kregzdyte@lsmuni.lt

    Dalė Baranauskienė, PhD, dale.baranauskiene2@lsmuni.lt

    Jurgita Šulinskienė, PhD, jurgita.sulinskiene@lsmuni.lt

    Vaida Šimakauskienė, vaida.simakauskiene@lsmuni.lt

    Arvydas Laukevičius, arvydas.laukevicius@lsmuni.lt

    Gabrielė Janušauskaitė, gabriele.janusauskaite@lsmuni.lt

    Lionė Grabauskienė, lione.grabauskiene@lsmuni.lt

    Aldona Švėgždienė, aldona.svegzdiene@lsmuni.lt

     

    Laboratory short history 

    Laboratory of Toxicology (from 2011-07-01 till 2018-01-01 was Laboratory of Neurotoxicology) was established in 2011 via reorganization of the Laboratory for Environmental Health Research. The latter Laboratory was established in 2005 after merger of Laboratory for Anthropogenic Factors Research and Laboratory of Ecological Monitoring of Human Health. These laboratories were established in 1989 for implementation of Lithuanian State Program of Ecological Monitoring. Researchers of the Laboratory were innovators in Lithuania of heavy metals and trace elements investigation and assessment in various biological media (human hair, blood, urine, and biopsy material, experimental animals, etc). The focus of Laboratory research is investigation of trace elements and their biomarkers in connection with public health, occupational health, and clinical research (e.g. trace elements equilibrium in patients with chronic kidney insufficiency, manganese as prognostic value of hepatic encephalopathy, disorders of copper metabolism in patients with Wilson’s disease, involvement of cadmium in pathogenesis of breast cancer, etc.).

    There were 9 PhD thesis defended at the Laboratory during 1989-2011.

     

    Research topic

    Title: The role of trace elements in pathogenesis and prevention of brain tumours

    Glioblastomas are the most common and the most aggressive malignant primary brain tumours in humans. In spite of multiple therapies the survival rate is only 12-14 months after diagnosis. These tumours are resistant to treatment and frequently implicate multidrug resistance phenotype. The mechanisms are not fully understood though it is known that metallothioneins (MT) might be involved in forming multidrug resistance. Metallothioneins are intracellular low molecular weight proteins, MTs function is not clear, but experimental data suggest MTs may provide protection against heavy metal toxicity, be involved in regulation of physiological metals (Zn and Cu) and provide protection against oxidative stress. The MT expression in some tumours correlates with degree of malignancy and tumour growth rate. It is established that single nucleotide polymorphism SNP of the gene MT2A is involved in accumulation of Cd, bioaccessibility of Zn, and Mg and Fe amount in blood. Therefore, the data on relation between trace elements, metallothioneins and MT gene polymorphism are lacking.

     

    Main projects

    2017-2021 – contribute in the EC programme Horizon 2020 funded project HBM4EU (The European Human Biomonitoring Initiative), Grant agreement No. 733032, dr. L.Strumylaitė

    2013-2015 – contribute in the Global grant project* VP1-3.1-ŠMM-07-K-02-060 „Gene-Environment Interactions Connecting Low Triiodothyronine Syndrome and Outcomes of Cardiovascular Disease (GET-VASC)”, dr. R.Naginienė

    2009 – project No T-64/09 "The assessment of the relationship between cadmium and the risk of breast cancer", funded by Lithuania State Science and Studies Foundation, head dr. L.Strumylaitė

    2007-2009 – EC 6FP project SSPE-CT-2007-044159 PRONET (Pollution Reduction Options Network), Lithuania deputy dr. R.Naginienė

    2005-2007 – Implementation the EU Council Directive 77/312EEB on Biological Screening of the Population for Lead, dr. R.Naginienė

    2003-2005 – EC 5FP project QLK4-2002-02395 PINCHE (Policy Interpretation Network on Children’s Health and Environment), Lithuania deputy dr. R.Naginienė

     

    International collaboration

    Since 2006, the Laboratory is Lithuanian Satellite Centre of Trace Element Institute for UNESCO.

     

    pdf-logo.jpg (90x68, 68x68)  2017 - 2011 main publications

     


    Updated on 11 September 2018

  • Laboratory of Ophthalmology

    Address:

    Laboratory of Ophthalmology
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania
     
    Phone: +370 37 326749

     

    Head of the laboratory

    Rasa Liutkevičienė, PhD, rasa.liutkeviciene@kaunoklinikos.lt

    Personnel:

    Loresa Kriaučiūnienė, PhD, loresa.kriauciuniene@lsmuni.lt

    Alvita Vilkevičiūtė, PhD student, alvita.vilkeviciute@lsmuni.lt

    Greta Gedvilaitė, greta.gedvilaite@lsmuni.lt

    Kristė Kaikarytė, kriste.kaikaryte@lsmuni.lt

     

    Laboratory short history

    Laboratory was established in 1992. The areas of scientific research are: epidemiologic investigation of eye diseases; complex ultrasonic investigation of structure, dimensions and haemodynamics of ocular tissue; storing and processing of ophthalmological images and signals for interactive and automatic multi-criterial clinical decision support. During collaboration with Sweden, Holland, Brazil in international E-Health and Telemedicine projects, infrastructure for scientific research in virtual environment was established. In 2003 Telemedicine centre of Kaunas University of Medicine (Lithuanian University of Health Sciences since 2011) was established, that is now institutional member of International Society for Telemedicine and e-Health (ISfTeH).

    In the Laboratory 12 doctoral dissertations have been defended.

    The Laboratory was awarded with eEurope Award for e-Health 2003 “e-Health NetLit (LT)"  - a Finalist Diploma in a High Level Conference and Exhibition on e-Health, Brussels, 22, 23 April 2003.

     

    Research topic

    Title: Relation of the eye neurosensoric function to genotype and fenotype in age related macular degeneration

    Age related macular degeneration (AMD) – age related neurodegenerative disease of macula – central part of the retina. It leads to considerable visual loss. AMD is one of main causes of blindness in people in age over 60. Because of progressive loss of central visual function, it has marked influence to patient behaviour and life quality. In 2002 in Lithuania was 13.8% blind people because of AMD. In 2020 the amount of handicapped people because of AMD will increase to 16.5%. Unfortunately, today AMD is not treatable. However, up to now there is no proper treatment for age-related macular degeneration though novel treatment methods can stop progression of AMD and to help avoid blindness. That is why new information about pathogenesis of AMD can support development of the new methods of treatment and prevention of this disease.

    Diagnosis, observation of course and treatment of AMD needs high resolution imaging technologies, parameterisation and high skilled ophthalmologist evaluation. Quantitative evaluation of this visual information could be achieved using biophysical models based imaging and quantitative evaluation methods.

    Researchers of Laboratory of Ophthalmology in collaboration with Laboratory for Biophysics and Bioinformatics are planning to collaborate for biophysical models based biomedical signal and image analysis methods to process a big amount of information from biomedical signals, images, clearing up changes in eye neurosensoric function in AMD and reflecting the relation to genetic polymorpfisms. For this purpose some genetic markers (MMP-2 -1306C/T and -735C/T, MMP-3, -1171 5A/6A, MMP-9 -1562C/T, ApoE) will be investigated.

     

    Main projects

    2016-2017 – collaboration in the LSMU-KTU project "Elaboration and employment of virtual reality stimuli to investigate peripheral vestibular function employing innovative device (VIRVEST)", dr. R.Liutkevičienė

    2015-2018 – project No SEN-11/2015 "New genetic and metabolic biomarkers search in healthy subjects and patients with age-related macular degeneration", funded by the Research Council of Lithuania, head prof. V.P.Deltuva

    2015-2016 – collaboration in the Lithuanian-Japan project "Analysis of biomarkers discovered by using S.Pombe in human blood", dr. R.Liutkevičienė

    2014-2016 – contribute in the project MIP-008/2014 " New molecular prognostic markers search in pituitary adenomas and associations with visual functions", funded by the Research Council of Lithuania, dr. R.Liutkevičienė

    2014-2015 – collaboration in the LSMU-KTU project "Elaboration of innovative device to investigate peripheral vestibular function", dr. R.Liutkevičienė

    2013-2015 – post doc project BioMONDA "Multimodal data analysis of optic nerve and it's environment based on biophysical models", funded by the Research Council of Lithuania, dr. Asta Kybartaitė-Žilienė

     

    pdf-logo.jpg (90x68, 68x68)  2017 - 2011 main publications

     


    Updated on 11 September 2018

  • Laboratory for Research of Pharmacological Regulation of Pathological Processes and Drug Metabolism

     

    Address:

    Laboratory for Research of Pharmacological Regulation of Pathological Processes and Drug Metabolism
    Neuroscience Institute
    Lithuanian University of Health Sciences
    Eiveniu st. 4
    Kaunas LT-50161
    Lithuania

     

     

    The Laboratory for Research of Pharmacological Regulation of Pathological Processes and Drug Metabolism funcions in the Advanced Pharmaceutical and Health Technologies Centre of Lithuanian University of Health Sciences.

     

    Updated on 11 September 2018