Institute of Endocrinology

  • About Institute

    Institute of Endocrinology

    Institute of Endocrinology of the Medical Academy of Lithuanian University of Health Sciences was established in 1978,Institute of Endocrinology and since 1994 became a part of the current Medical Academy of Lithuanian University of Health Sciences (LUHS)

    The principal aim of IE is to carry out fundamental, clinical and epidemiological research in the field of endocrine pathology and act as a scientific base for doctoral studies of PhD students, as well as improvement of scientific competence for academic personnel at LUHS.

    The institute consists of two laboratories – diabetes and general endocrinology. The major activities cover fundamental and clinical research in the field of biomedical sciences, including Biology (B01) and Medicine (B06).

    The scope of current scientific work focuses on the following directions:

    1. Investigation of environmental and genetic factors in predicting human reproductive health.
    2. Investigation of molecular mechanisms and clinical features of neuroendocrine regulation and its disorders.
    3. Registry for patients with diabetes, impact of immune, genetic and environmental factors on the disease etiology, prevention and treatment strategy.

     

    At EI there are 31 employees (among them 3 professors, 3 PhD students), 21 scientists, 7 research personnel, 2 administrative staff, 1 hosehold staff.

     

  • Research

    1. Laboratory of General Endocrinology:

    1.1. Investigation of environmental and genetic factors in predicting human reproductive health:

    1.1.1. Physical and psychological assessment of men with hypogonadotropic hypogonadism undergoing testosterone replacement therapy;

    1.1.2. Relationship of reproductive health parameters with genetic and environmental factors in men of all ages;

    1.1.3. Association between hormonal contraception use, environmental and genetic factors and reproductive health in women.

    1.2. Investigation of molecular mechanisms and clinical features of neuroendocrine regulation and its disorders:

    1.2.1. Clinical, genetic and proteomics investigations in the assessment of pathogenesis and possible treatment options of hypothalamic-pituitary disorders;

    1.2.2. The investigation for new combinations of clinical, genetic and epigenetic markers in thyroid diseases.

    2. Laboratory of Diabetes Mellitus:

    2.1  Registry for patients with diabetes, impact of immune, genetic and environmental factors on the disease etiology, prevention and treatment strategy:

    2.1.1. Prevention of type 2 diabetes mellitus;

    2.2.1. Impact of obesity and gestational diabetes to female and children health;

    2.3.1. Register of type 1 diabetes mellitus;

    2.4.1. Complications of type 1 and type 2 diabetes mellitus;

    2.5.1. Diabetic neuropathy in patients with type 1 and type 2 diabetes mellitus;

    2.6.1. Diabetic retinopathy in patients with type 1 and type 2 diabetes mellitus;

    2.7.1. Stress and sleep relationships with emotional status and life quality of type 2 diabetic patients with metabolic syndrome.

     

  • Studies

    Laboratory of  Diabetes Mellitus:

    1. Laura Kazlauskienė. Correlations of metabolic syndrome and identified neuropsychiatric disorders with cardiovascular events (Supervisor prof. habil. dr. Antanas Norkus).
    2. Miglė Francaitė – Daugelienė. The influence of gestational diabetes and obesity on health of mothers and their offspring (Supervisor Dr. Džilda Veličkienė).
    1. Dr. Audronė Šeibokaitė. Evaluation of physical and psychological health state of patients with childhood-onset hypopituitarism after growth hormone treatment disconrinuation (Supervisor prof. habil. dr. Liudvikas Lašas, Date of PhD thesis defence 28 of August 2011).
    2. Dr. Marius Diržauskas. Study of time to pregnancy prognostic factors (Supervisor prof. Birutė Žilaitienė, Date of PhD thesis defence 29 of August 2012).
    3. Dr. Dalia Daukšienė. Prognostic factors predicting the medical therapy failure in Graves' disease (Supervisor dr. Narseta Mickuvienė, Date of PhD thesis defence 28 of August 2013).
    4. Dr. Jonas Čeponis. Reproductive function of young and middle-aged men: relation to antropometric, metabolic and psychological state (Supervisor PhD Romualdas Tomas Preikša, Date of PhD thesis defence 6 of June 2014).
    5. Lina Čiaplinskienė. The impact of hormonal contraception on the changes of metabolic, androgen, blood coagulation parameters and sexual function in female. (Supervisor prof. Birutė Žilaitienė, Consultant prof. Johannes Bitzer).

    Attendance in COST activities:

    Assoc. prof. habil. dr. Valentinas Matulevičius. MPNS COST Action TD1103. European Network for Hyperpolarization Physics and Methodology in NMR and MRI.

    Prof. Rasa Verkauskienė, dr. Romualdas Tomas Preikša, prof. Birutė Žilaitienė, dr. Jonas Čeponis Cost Action BM1105. GnRH Deficiency: Elucidation of the neuroendocrine control of human reproduction.

  • Projects

    Long term consequences of gestational diabetes and obesity on health of mothers and their offspring MIP-14192/2014

    Aim: To evaluate long term consequences of gestational diabetes on health of mothers and their offspring.

    Objectives:

    1. To assess the prevalence of obesity in women of reproductive age 15-20 years period.
    2.  Long term consequences evaluation (>15years) of gestational diabetes/obesity for mothers and their children's health (carbohydrate, lipid metabolism, body composition, mental health, eating habits, physical activity, social status, diabetes and cardiovascular the risk of disease).
    3.  To compare the results of sibling, who were born in the pathological pregnancy complicated gestational diabetes and / or obesity and normal pregnancy, health condition.
    4.  To assess the frequency of complications of diabetes in subjects with impaired glucose tolerance or diabetes.
    5.  To evaluate type 2 diabetes mellitus mostly predisposing gene TCF7L2 single nucleotide polymorphisms (rs7901695, rs7903146, rs7895340, rs11196205, rs12255372) with history of gestational diabetes in women and their children.
    6. To prepare examination, monitoring and treatment recommendations for women who have been diagnosed with gestational diabetes.
    7. To prepare examination and monitoring recommendations offspring whose mothers had gestational diabetes identified.

    Cardiometabolic risk factors in Turner syndrome: prospective one population cohort study

    The aim of the study: To identify the cardiometabolic risk factors in Turner syndrome (TS) population in Lithuania.

    Objects:

    1.  To investigate the prevalence of aortic lesions by using radiological evaluation methods (cardioechoscopy, magnetic resonance imaging) in TS population.

    2.  To identify the association between congenital cardiovascular abnormalities and aortic dilation in the assessed group.

    3.  To evaluate the influence of metabolic disorders and hormonal imbalance to aortic dilation in TS.

    4. To compare the prevalence of Fibrilin-1 gene (FBL-1) single nucleotide polymorphisms (SNP) rs10519177 and  rs211818 between TS and healthy females.

    5. To identify the correlation between FBL-1 SNP’s rs10519177 and  rs211818 and aortic diameter in TS.

    6. To evaluate the correlation between cardiometabolic disorders, hormone imbalance and genetic features and aortic diameter changes in TS during 18 mounths.

    7. To assess the psychoemotional state, congenital functions, sexual function and quality of life in TS population.

    Genetic diabetes in Lithuania

    The programme "Research and Development" is a constituent part of the Lithuanian-Swiss cooperation programme. Project “Genetic diabetes in Lithuania” was developed in the frame of this programme based on the up-to-date scientific knowledge. The aim of this study is to screen diabetic children and young adults who have no signs of autoimmunity (i.e. lack of antibodies typically associated with Type 1) or who present with diabetes associated with congenital malformations of the pancreas. Setting aside the origin of autoimmune diabetes in patients diagnosed with genetic diabetes, they will be permitted to switch from insulin to oral therapy products. This is the first and unique opportunity in Lithuania for patients to diagnose genetic diabetes free.

    The project is funded by the support of Swiss Confederation and the Republic of Lithuania's budget. Project started in November 2012 and will last till April 2016. The project budget is 6.684.38.87€.

     

     

    e-PREDICE

    “Early Prevention of Diabetes Complications in Europe” was funded by SEVENTH FRAMEWORK PROGRAMME. General objective of project is to assess the long-term effects of different therapeutic regimens, both pharmacological and lifestyle interventions, for the early prevention of diabetic complications in people with intermediate hyperglycaemia (IFG or IGT) and screen-detected diabetes (SD-T2D). During the research 3000 45-74-year-aged patients from 12 countries will be examined. Project budget is 8.212.206.89€, Lithuanian part – 224.864.00 € Project duration is 1st of January 2012 - 31st of December 2016.

     

    MANAGE-CARE

    “Active ageing with type 2 diabetes as model for development and implementation of innovative chronic care management in Europe (MANAGE-CARE)” was funded by SEVENTH FRAMEWORK PROGRAMME. MANAGE-CARE focuses on prevention of costly complications and hospitalizations of patients with chronic diseases with diabetes as a model disease.

    Project budget is 1.154.069.00 €, Lithuanian part – 14.659.00 € Project started in May 2013 and will last till April 2016.

  • Contacts

    Prof. Rasa Verkauskienė
    Director

    Phone: +370 37 327097 (Local LUHS 7097)
    E-mail: rasa.verkauskiene@gmail.com

    Laboratory of  Diabetes Mellitus

    Dr. Džilda Veličkienė
    Laboratory Manager
    Senior Researcher
    Phone: +370 37 326699 (Local LUHS 6699)
    E-mail: Dzilda.Velickiene@lsmuni.lt

    Prof. habil. dr. Antanas Norkus 
    Chief Researcher
    Phone: Local LUHS 6699
    E-mail: diabetas.kaunas@gmail.com

    Dr. Rytas Ostrauskas
    Deputy Director for Science
    Chief Researcher
    Phone: +370 37 798607 (Local LUHS 4247) Fax: +370 37 331882
    E-mail: rytas.o@gmail.com

    Dr. Rimantas Žalinkevičius
    Chief Researcher
    Phone: Local LUHS 6482
    E-mail: rimantas.zalinkevicius@med.kmu.lt

    Dr. Bronislava Urbonaitė
    Chief Researcher
    Phone: +370 37 730709
    E-mail: brone.u@takas.lt

    Dr. Nijolė Jurgevičienė
    Senior Researcher
    Phone: Local LUHS 6482
    E-mail: nijolejurgeviciene@takas.lt

    Dr. Dalia Marčiulionytė
    Senior Researcher
    Phone: +370 37 730709
    E-mail: dalia.m@takas.lt 

    Dr. Rita Šulcaitė 
    Senior Researcher
    Phone: Local LUHS 6699
    E-mail: rita.sulcaite@gmail.com  

    Dr. Lina Lašaitė 
    Senior Researcher
    Phone: +370 37 730709
    E-mail: linlasla@yahoo.com

    Dr. Jūratė Butnorienė
    Researcher
    Phone: Local LUHS 6699
    E-mail: juratebutnoriene@yahoo.com

    Dr. Evalda Danytė
    Researcher
    E-mail: evalda.danyte@gmail.com

    Dr. Lina Radzevičienė
    Senior Researcher
    Phone: Local LUHS 6699
    E-mail: lina_radzeviciene@yahoo.com

    Miglė Francaitė - Daugelienė
    PhD student
    E-mail: francaite@yahoo.com

    Laura Kazlauskienė
    PhD student
    Phone:  +370 687 14706
    E-mail: brauklyte@yahoo.com

    Laboratory of General Endocrinology

    Prof. Birutė Žilaitienė
    Laboratory Manager
    Chief Researcher
    Phone:  +370 37 32 68 68 (Local LUHS 6506)
    E-mail: Birute.Zilaitiene@lsmuni.lt

    Doc. habil. dr. Valentinas Matulevičius
    Senior Researcher
    Phone: +370 37 730709 (Local LUHS 6381)
    E-mail: valentinasmatulevicius@ymail.com

    Dr. Romualdas Tomas Preikša
    Senior Researcher
    Phone: +370 37 730709 (Local LUHS 6370)
    E-mail: preiksar@takas.lt

    Dr. Rimantas Henrikas Kublickas 
    Researcher
    E-mail: rimantas.kublickas@ktu.lt

    Dr. Vygantas Šidlauskas
    Junior Researcher
    Phone: +370 37 798498
    E-mail: skydliauke@takas.lt

    Dr. Audronė Šeibokaitė
    Junior Researcher
    Phone: +370 37 798493
    E-mail: audroneshb@yahoo.com

    Dr. Loreta Dunderienė
    Junior Researcher
    Phone: +370 37 798498
    E-mail: loretarad@yahoo.com   

    Dr. Jonas Čeponis
    Junior Researcher
    Phone: +370  652 73 522
    E-mail: ceponis@gmail.com

    Dr. Dalia Daukšienė
    Junior Researcher
    E-mail: dalia.dauksiene@gmail.com

    Lina Čiaplinksienė
    Laboratory assistant, PhD student
    E-mail: lina.mozuraite@gmail.com

     

    Contacts