Granted by Lithuanian Research Council

“Relations among heart diseases, psycho-emotional and sleep disturbances; their impact on life quality“. (contract No LIG-03/2012). The leader prof.habil.dr. G. Varoneckas (CV)


The aim of the research is to investigate the dynamic of relations among psycho-emotional, sleep disturbances and cardiovascular disorders as well as their impact on health-related quality of life and to prepare recommendations for correction of risk factors.

Repeated epidemiological study will be performed among Palanga citizens. The relations among prevalence of insomnia and depression, social, biological, health behaviour factors, coronary artery disease (CAD) and health-related quality of life will be investigated.

1602 persons were investigated during the first study, performed in 2003-2004. It is expected to investigate 1000 persons from the same contingent (65% of invited to participate persons) during repeated study after 10 years. The impact of cardiovascular risk factors will be evaluated and the mathematical model for prediction of cardiovascular risk factors will be developed.

Clinical research will be performed; the relations among psycho-emotional status, sleep quality and cardiovascular status in CAD patients will be assessed. It is expected that clinical data base will be formed of 2000 records of CAD patients.  The relation among risk factors, tiredness, anxiety, depression, sleep quality and cardiovascular disease will be investigated.

The project results will serve as a scientific background for long lasting strategy formation for prevention and control of cardiovascular disorders. The strategy will lead to effectively decreased rates of morbidity and mortality due to cardiovascular disorders and external reasons.


“Impact of mental disorders and metabolic syndrome on mortality in primary health care patients“ (contract No.LIG-03/2011).Projekt manager habil dr. R.Bunevičius


Mental disorders such as depression are directly related to morbidity and mortality from various diseases, particularly from cardiovascular diseases. Metabolic syndrome as a combination of medical disorders that, when occurring together, increase. the incidence of cardiovascular diseases and early death rate. Various biological, behavioral factors link metabolic syndrome to mental disorders. Their interaction can affect the course of somatic diseases, mortality, including mortality from external causes. Project objective isto investigate the prevalence of mental disorders and their links to suicidal ideation, alcohol consumption, metabolic syndrome and mortality in the primary health care level. The survey is conducted in two phases. Patients who request to consult a family doctor will be evaluated in the first phase. In the second phase-population of subjects registered in primary health care centers will be evaluated prospectively. Medical records will be used from cross-sectional study database collected in 2004, in one of the region of Lithuania. Necessary information will be obtained from evaluation of medical records, and statistics.

Project results will help identify and assess the problems faced by family doctors diagnosing mental disorders, suicidal tendencies and risky alcohol consumption: provide new insights into links between mental disorders with insulin resistance, metabolic syndrome, cardiovascular events, and provide information about influence of somatic factors on mental disorders and manifestation of their complications. Obtained data will enable support of mental, somatic diseases prevention strategies, taking into account the lifestyle and biological factors; to develop their risk-assessment methodology.


“Factors determining quality of life and outcomes in patients with ischemic heart disease”.(contract No LIG-04/2011). The leader dr. N.Mickuvienė


Research priority in new cardiovascular diseases studies is related with research of complex inflammatory, hormonal and genetic markers to predict outcome for CHD. Recently, great attention is paid to inflammatory markers, and hormonal factors influence to cardiovascular functional status, quality of life of patients with ischemic heart disease outcomes. Therefore, it is important to comprehensively assess the hormonal and inflammatory markers in patients with ischemic heart disease for long-term impact on quality of life, disease course and outcome. The project will aim to establish long-term quality of life in breach of the factors - mental disorders, psychosocial factors and their links with hormones and inflammatory markers on purpose to exclude the most vulnerable groups. The stated objectives will be used to examine cross-sectional cohort study long-term clinical follow-up data. Will be investigated in patients with CHD long-term quality of life, mental disorders, psychosocial factors, inflammatory (interleukin-6 and high sensitivity CRP) and hormones (NT-pro-BNP, TSH, FT4, FT3, RT3) signs, the disease course and outcome. Tasks will be used to examine the cumulative clinical cohort of long-term monitoring data and blood serum.
This project will disentangle factors such as mental disorders (depression, anxiety and type D personality, fatigue) and psychosocial factors (social support, social events values), and inflammatory (high-sensitivity CRP, interleukin-6) and hormonal markers (hormone NT-pro-BNP, TSH, FT4, FT3, RT3)effecting long-term quality of life. The purpose of the project is to detect vulnerable groups of patients with CHD.